Abstract
Ammonia is believed to have a significant role in the pathogenesis of a number of neurological disorders. The exact mechanism of ammonia neurotoxicity, however, is still poorly understood. In view of current evidence implicatingastrocytes in ammonia metabolism as well as morphological observations suggesting the astrocyte as the target of ammonia toxicity, we have investigated the effects of ammonia on astrocytes in primary culture. Especially with higher concentrations and longer exposure, the results indicate that ammonia induces astrocytic injury associated with functional failure. These astrocytic alterations may contribute to the pathogenesis of ammonia encephalopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 353-362 |
| Number of pages | 10 |
| Journal | Advances in the Biosciences |
| Volume | 61 |
| Issue number | C |
| State | Published - Dec 1 1986 |
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Keywords
- Ammonia
- astrocytes
- encephalopathy
- neurotransmitters
- potassium
- tissue culture
Cite this
Effects of ammonia in primary astrocyte cultures morphological and biochemical considerations. / Norenberg, Michael D; Mozes, L. W.; Norenberg, L. O B; Gregorios, J. B.
In: Advances in the Biosciences, Vol. 61, No. C, 01.12.1986, p. 353-362.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of ammonia in primary astrocyte cultures morphological and biochemical considerations
AU - Norenberg, Michael D
AU - Mozes, L. W.
AU - Norenberg, L. O B
AU - Gregorios, J. B.
PY - 1986/12/1
Y1 - 1986/12/1
N2 - Ammonia is believed to have a significant role in the pathogenesis of a number of neurological disorders. The exact mechanism of ammonia neurotoxicity, however, is still poorly understood. In view of current evidence implicatingastrocytes in ammonia metabolism as well as morphological observations suggesting the astrocyte as the target of ammonia toxicity, we have investigated the effects of ammonia on astrocytes in primary culture. Especially with higher concentrations and longer exposure, the results indicate that ammonia induces astrocytic injury associated with functional failure. These astrocytic alterations may contribute to the pathogenesis of ammonia encephalopathy.
AB - Ammonia is believed to have a significant role in the pathogenesis of a number of neurological disorders. The exact mechanism of ammonia neurotoxicity, however, is still poorly understood. In view of current evidence implicatingastrocytes in ammonia metabolism as well as morphological observations suggesting the astrocyte as the target of ammonia toxicity, we have investigated the effects of ammonia on astrocytes in primary culture. Especially with higher concentrations and longer exposure, the results indicate that ammonia induces astrocytic injury associated with functional failure. These astrocytic alterations may contribute to the pathogenesis of ammonia encephalopathy.
KW - Ammonia
KW - astrocytes
KW - encephalopathy
KW - neurotransmitters
KW - potassium
KW - tissue culture
UR - http://www.scopus.com/inward/record.url?scp=0342591376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0342591376&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0342591376
VL - 61
SP - 353
EP - 362
JO - Advances in the Biosciences
JF - Advances in the Biosciences
SN - 0065-3446
IS - C
ER -