Effects of aminophylline on respiratory center and reflex activity in premature infants with apnea

T. Gerhardt, J. McCarthy, Eduardo Bancalari

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Fourteen preterm infants with apnea (body weight, 1052 ± 44 g; gestational age, 30.2 ± 0.5 wks; and postnatal age, 9.9 ± 1.5 days) were studied in an effort to evaluate the effects of aminophylline on respiratory center output and respiratory reflex activity in the preterm infant with idiopathic apnea. This was done by using the airway occlusion technique. The infants were studied before and 48 hr after aminophylline was begun as a treatment for apnea. Occlusion pressure, which reflects respiratory center output, was measured at 100 msec after occlusion started (P100) and at its maximum (Pmo). P100 increased from 2.4 ± 0.2 to 3.1 ± 0.2 cmH2O (P < 0.005), and Pmo from 6.1 ± 0.7 to 8.8 ± 1.0 cmH2O (P < 0.001) after aminophylline therapy was started. The % prolongation of inspiratory time during the occluded breaths, when compared to the unoccluded breaths increased from 26.2 ± 10.6 to 55.8 ± 12.5% (P < 0.01). This reflects a significant increase in the strength of the Hering Breuer reflex. Effective elastance, a measure of respiratory load compensation, was significantly higher during aminophylline treatment. It increased from 1.09 ± 0.14 to 1.33 ± 0.14 cmH2O/ml (P < 0.02).

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalPediatric Research
Volume17
Issue number3
StatePublished - Jan 1 1983

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Respiratory Center
Aminophylline
Apnea
Premature Infants
Reflex
Gestational Age
Therapeutics
Body Weight
Pressure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of aminophylline on respiratory center and reflex activity in premature infants with apnea. / Gerhardt, T.; McCarthy, J.; Bancalari, Eduardo.

In: Pediatric Research, Vol. 17, No. 3, 01.01.1983, p. 188-191.

Research output: Contribution to journalArticle

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