Effects of Aging on Metabolic Characteristics of Human B Cells

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Metabolic changes represent the most common sign of aging and lead to increased risk of developing diseases typical of old age. Age-associated metabolic changes, such as decreased insulin sensitivity, decreased mitochondrial function, and dysregulated nutrient uptake, fuel the low-grade chronic systemic inflammation, known as inflammaging, a leading cause of morbidity and mortality, linked to the development of several diseases of old age. How aging affects the metabolic phenotype of immune cells, and B cells in particular, is not well known and is under intensive investigation by several groups. In this study, we summarized the few published results linking intrinsic B-cell metabolism and B-cell function in different groups of young and elderly individuals: healthy, with type-2 diabetes mellitus, or with HIV infection. Although preliminary, these results suggest the intriguing possibility that metabolic pathways can represent potential novel therapeutic targets to reduce inflammaging and improve humoral immunity.

Original languageEnglish (US)
Pages (from-to)S23-S28
JournalJournal of Acquired Immune Deficiency Syndromes
StatePublished - Feb 1 2022
Externally publishedYes


  • Aging
  • Humoral immunity
  • Inflammation
  • Metabolism

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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