Effects of aging on B cell function

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalCurrent Opinion in Immunology
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2009

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B-Lymphocytes
Genetic Recombination
B-Lymphocyte Subsets
Microarray Analysis
Transcription Factors
Vaccines
Animal Models
AICDA (activation-induced cytidine deaminase)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effects of aging on B cell function. / Frasca, Daniela; Blomberg, Bonnie B.

In: Current Opinion in Immunology, Vol. 21, No. 4, 01.08.2009, p. 425-430.

Research output: Contribution to journalArticle

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