Effects of aerobic exercise training on lymphocyte subpopulations

A. LaPerriere, M. H. Antoni, G. Ironson, A. Perry, P. McCabe, N. Klimas, L. Helder, N. Schneiderman, Mary Ann Fletcher

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


This study was conducted to determine the effects of an aerobic exercise training program on subpopulations of lymphocyte phenotypes. Fourteen healthy but sedentary males, 18-40 years of age, were randomly assigned to either an aerobic exercise training or control condition. Aerobic exercise training consisted of three 45-minute sessions of cycle ergometry exercise per week at 70-80% of age-predicted maximum heart rate for ten weeks. The aerobic exercise training resulted in a significant decrease in submaximal heart rate from 176 to 150 beats per minute to a fixed work rate of 150 watts (p<.01). This training effect was accompanied by increases in the resting level of the following lymphocyte subpopulations: CD2 (1717 vs 2183 mm3; p<.01), CD4 (942 vs 1280mm3; p<.01), CD45RA+CD4+(312 vs 595mm3; p<.01), CD8 (655 vs 816mm3; p<.05), and CD20 (162 vs 244 mm3; p<.01) cell counts. These findings indicate that several lymphocyte subpopulations are increased following a 10-week program of aerobic exercise training.

Original languageEnglish (US)
Pages (from-to)S127-S130
JournalInternational Journal of Sports Medicine
Issue numberSUPPL. 3
StatePublished - Jan 1 1994


  • Aerobic training
  • Exercise
  • Immune system
  • Lymphocyte phenotypes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation


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