Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma

Matthew Z. Sun, Michael E. Ivan, Michael C. Oh, Arthur R. Delance, Aaron J. Clark, Michael Safaee, Taemin Oh, Gurvinder Kaur, Annette Molinaro, Nalin Gupta, Andrew T. Parsa

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Choroid plexus carcinoma (CPCs) is a rare, malignant, primary brain tumor with a poor prognosis. Currently, there is no consensus on the use of adjuvant therapy, and few large-scale studies focus exclusively on the pediatric population. We performed a comprehensive systematic review of pediatric CPCs to determine the effects of various adjuvant therapy modalities on overall survival (OS). A literature search was performed to identify studies reporting children with CPC who underwent surgical resection. Only patients who had clearly received adjuvant therapy, or were described as not selected for adjuvant therapy were analyzed in our comparison groups. Kaplan–Meier and multivariate Cox regression survival analyses were performed to determine the effects of different types of adjuvant therapies on OS. A total of 135 children (age ≤ 18 years) with CPC who had known adjuvant therapy status and OS were identified from 53 articles. Kaplan–Meier analysis showed that while adjuvant therapy overall improved OS (p = 0.001), different modes of adjuvant therapies had varying effects on OS (p = 0.034). Specifically, combined chemo-radiotherapy as well as chemotherapy alone improved OS (p = 0.001), but radiation did not (p = 0.129). Multivariate Cox proportional hazard model adjusting for confounding factors showed that combined therapy was associated with better OS compared to chemotherapy alone (HR: 0.291, p = 0.027). Both chemotherapy alone and combined chemo-radiation improved OS independent of age, gender, tumor location and extent of resection, while radiation alone did not.

Original languageEnglish (US)
Pages (from-to)353-360
Number of pages8
JournalJournal of neuro-oncology
Issue number2
StatePublished - Oct 22 2014
Externally publishedYes


  • Adjuvant therapy
  • Chemotherapy
  • Choroid plexus carcinoma
  • Overall survival
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


Dive into the research topics of 'Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma'. Together they form a unique fingerprint.

Cite this