Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice.

Mitsuko L. Yamamoto, Kurt Hafer, Ramune Reliene, Sheila Fleming, Owen Kelly, Katrin Hacke, Robert H. Schiestl

Research output: Contribution to journalArticle

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Abstract

As therapeutic uses of high-LET radiation become more prevalent and human space exploration continues to be a focus of NASA, it is important to understand the biological effects of high-LET radiation and the role of genetics in sensitivity to high-LET radiation. To study genetic susceptibility to radiation, we used mice deficient in Atm activity (AtmΔSRI). ATM is important in DNA repair, apoptosis and cell cycle regulation. Although homozygous mutations in ATM are rare, the prevalence of ATM heterozygosity is estimated to be 1% and results in an increased cancer risk. We found that the effects of 1 Gy 1 GeV/nucleon Fe particles on life span and tumorigenesis are genotype- and sex-specific. Significant effects of 1 Gy 1 GeV/nucleon Fe particles on incidence of non-cancer end points were seen; however, 2 Gy 1 GeV/nucleon Fe particles significantly affected neuromotor ability. Our results represent an extensive investigation into the late effects of high-LET radiation exposure in a sex- and genotype-dependent manner and provide a baseline for understanding the long-term risks of high-LET radiation.

Original languageEnglish (US)
Pages (from-to)231-239
Number of pages9
JournalRadiation Research
Volume175
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Linear Energy Transfer
mice
Carcinogenesis
asynchronous transfer mode
Radiation
radiation
Radiation Genetics
Genotype
United States National Aeronautics and Space Administration
life span
Space Flight
biological effects
space exploration
radiation dosage
apoptosis
Therapeutic Uses
Genetic Predisposition to Disease
mutations
DNA Repair
Cell Cycle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Yamamoto, M. L., Hafer, K., Reliene, R., Fleming, S., Kelly, O., Hacke, K., & Schiestl, R. H. (2011). Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice. Radiation Research, 175(2), 231-239. https://doi.org/10.1667/RR2312.1

Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice. / Yamamoto, Mitsuko L.; Hafer, Kurt; Reliene, Ramune; Fleming, Sheila; Kelly, Owen; Hacke, Katrin; Schiestl, Robert H.

In: Radiation Research, Vol. 175, No. 2, 02.2011, p. 231-239.

Research output: Contribution to journalArticle

Yamamoto, ML, Hafer, K, Reliene, R, Fleming, S, Kelly, O, Hacke, K & Schiestl, RH 2011, 'Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice.', Radiation Research, vol. 175, no. 2, pp. 231-239. https://doi.org/10.1667/RR2312.1
Yamamoto, Mitsuko L. ; Hafer, Kurt ; Reliene, Ramune ; Fleming, Sheila ; Kelly, Owen ; Hacke, Katrin ; Schiestl, Robert H. / Effects of 1 GeV/nucleon Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice. In: Radiation Research. 2011 ; Vol. 175, No. 2. pp. 231-239.
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