Abstract
The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 389-391 |
| Number of pages | 3 |
| Journal | Peptides |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1981 |
| Externally published | Yes |
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Keywords
- Active and passive avoidance behavior
- Open field activity
- β-(Tyr)melanotropin-(9-18)
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Effects of β-(Tyr9)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats. / Vécsei, L.; Telegdy, G.; Schally, Andrew V; Coy, D. H.
In: Peptides, Vol. 2, No. 4, 01.01.1981, p. 389-391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of β-(Tyr9)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats
AU - Vécsei, L.
AU - Telegdy, G.
AU - Schally, Andrew V
AU - Coy, D. H.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.
AB - The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.
KW - Active and passive avoidance behavior
KW - Open field activity
KW - β-(Tyr)melanotropin-(9-18)
UR - http://www.scopus.com/inward/record.url?scp=0019730521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019730521&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(81)80092-7
DO - 10.1016/S0196-9781(81)80092-7
M3 - Article
VL - 2
SP - 389
EP - 391
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 4
ER -