Effects of β-(Tyr9)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats

L. Vécsei; G. Telegdy; A. V. Schally; D. H. Coy

doi:10.1016/S0196-9781(81)80092-7

Effects of β-(Tyr⁹)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats

L. Vécsei, G. Telegdy, A. V. Schally, D. H. Coy

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The effects of the administration of β-(Tyr⁹)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr⁹)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr⁹)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.

Original language	English (US)
Pages (from-to)	389-391
Number of pages	3
Journal	Peptides
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/S0196-9781(81)80092-7
State	Published - Jan 1 1981
Externally published	Yes

Keywords

Active and passive avoidance behavior
Open field activity
β-(Tyr)melanotropin-(9-18)

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S0196-9781(81)80092-7

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title = "Effects of β-(Tyr9)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats",

abstract = "The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.",

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