Abstract
The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.
Original language | English (US) |
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Pages (from-to) | 389-391 |
Number of pages | 3 |
Journal | Peptides |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
Keywords
- Active and passive avoidance behavior
- Open field activity
- β-(Tyr)melanotropin-(9-18)
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience