Effects of β-(Tyr9)melantropin-(9-18) decapeptide on passive and active avoidance behavior and on open-field activity of rats

L. Vécsei, G. Telegdy, A. V. Schally, D. H. Coy

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The effects of the administration of β-(Tyr9)melanotropin-(9-18) into the lateral ventricle in a dose of 1.0 μg in 2 μl were studied on passive avoidance behavior, extinction of active avoidance behavior, and open-field activity in rats. β-(Tyr9)melanotropin-(9-18) given 30 min pretrial facilitated the acquisition of passive avoidance behavior; however, it was ineffective on retention when the material was given immediately posttrial or 30 min before retention testing. The extinction of active behavior was delayed. In open-field activity, the ambulation rate and rearing activity were increased 30 min following administration. The data suggest that β-(Tyr9)melanotropin-(9-18) has distinct neurotropic properties, and is able to modify behavioral reactions.

Original languageEnglish (US)
Pages (from-to)389-391
Number of pages3
JournalPeptides
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

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Keywords

  • Active and passive avoidance behavior
  • Open field activity
  • β-(Tyr)melanotropin-(9-18)

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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