Abstract
β-/Tyr9/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr9/melanotropin-/9-18/.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-96 |
| Number of pages | 6 |
| Journal | Neuropeptides |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
- Neurology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience
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Cite this
Vécsei, L., Telegdy, G., Schally, A. V., & Coy, D. H. (1982). Effects of β-/Tyr9/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine. Neuropeptides, 3(2), 91-96. https://doi.org/10.1016/0143-4179(82)90004-X