Effects of β-/Tyr9/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine

László Vécsei; Gyula Telegdy; Andrew V. Schally; David H. Coy

doi:10.1016/0143-4179(82)90004-X

Effects of β-/Tyr⁹/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine

László Vécsei, Gyula Telegdy, Andrew V. Schally, David H. Coy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

β-/Tyr⁹/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr⁹/melanotropin-/9-18/.

Original language	English (US)
Pages (from-to)	91-96
Number of pages	6
Journal	Neuropeptides
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/0143-4179(82)90004-X
State	Published - Dec 1982
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1016/0143-4179(82)90004-X

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title = "Effects of β-/Tyr9/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine",

abstract = "β-/Tyr9/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr9/melanotropin-/9-18/.",

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AU - Vécsei, László

AU - Telegdy, Gyula

AU - Schally, Andrew V.

AU - Coy, David H.

PY - 1982/12

Y1 - 1982/12

N2 - β-/Tyr9/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr9/melanotropin-/9-18/.

AB - β-/Tyr9/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr9/melanotropin-/9-18/.

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Effects of β-/Tyr⁹/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine

Abstract

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