Effects of β-/Tyr9/melanotropin-/9-18/ on apomorphine-induced stereotyped cage-climbing and on striatal dopamine release in mice. Comparative studies with amphetamine

László Vécsei, Gyula Telegdy, Andrew V. Schally, David H. Coy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

β-/Tyr9/melanotropin-/9-18/ significantly increased apomorphine-induced cage-climbing, while only a tendency towards an increase was observed after supersensitization with haloperidol. Amphetamine also enhanced apomorphine-induced climbing behavior. The peptide showed only a tendency to increase dopamine release from striatal slices, while amphetamine elevated this significantly. The results suggest that the striatal dopamine system is involved in the behavioral action of β-/Tyr9/melanotropin-/9-18/.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalNeuropeptides
Volume3
Issue number2
DOIs
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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