The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience