Effects of β-/Tyr9/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats

M. Fekete, G. Telegdy, A. V. Schally, D. H. Coy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effects of intracerebroventricular administration of a 1.0 ug dose of Tyr-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp /DC-11-18/ on the α-methyl-p-tyrosine /α-MPT/-induced catecholamine disappearance and the pargyline-induced serotonin accumulation in the hypothalmus, mesencephalon, amygdala, septum, cortex and striatum were studied. The dopamine disappearance was facilitated in the septum, while it was impeded in the striatum. The norepinephrine disappearance was lowered in the amygdala. The serotonin accumulation was inhibited in the hypothalamus and enhanced in the septum. The data indicate that this decapeptide is able to modify the activities of catecholamines and serotonin in different brain regions.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalNeuropeptides
Volume1
Issue number5
DOIs
StatePublished - Jun 1981
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Effects of β-/Tyr<sup>9</sup>/melanotropin-/9-18/ decapeptide on catecholamine disappearance and serotonin accumulation in discrete brain regions of rats'. Together they form a unique fingerprint.

  • Cite this