Effects of β-agonists on airway epithelial cells

Matthias A Salathe

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

β-Adrenergic receptor (βAR) agonists exert a variety of effects on airway epithelial cells. Among their best known actions is their ability to increase ciliary beat frequency, mediated by cyclic adenosine monophosphate (cAMP) production, stimulation of protein kinase A (PKA), and phosphorylation of an outer dynein arm light chain. Submucosal glands express βARs, and β-agonists may stimulate secretion of mucus from airways, although human data are controversial. β-Agonists may also affect ion transport across epithelial cells by opening apical ion channels such as the cystic fibrosis transmembrane regulator. This effect, likely to occur in submucosal glands, can influence water fluxes across the airway epithelium and may have profound influences on mucus hydration. βAR activation can increase intracellular calcium in some ciliated cells, thereby stimulating ciliary beating and possibly influencing transepithelial ion transport. βAR-mediated activation of cAMP-dependent protein kinase accelerates epithelial cell migration, thereby enhancing epithelial wound repair. β-Agonists reduce the ultrastructural damage seen with infection and potentiate secretion of certain cytokines from epithelial cells while inhibiting secretion of others. Finally, β-agonists may have effects on airway epithelial cells that are mediated through βARs but do not require cAMP production. The signaling mechanisms of some β-agonist effects are not well understood but are important to our understanding of airway epithelial cell growth, differentiation, and function.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Volume110
Issue number6 SUPPL.
DOIs
StatePublished - Dec 1 2002

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Epithelial Cells
Ion Transport
Mucus
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Adrenergic Receptors
Dyneins
Adrenergic Agonists
Ion Channels
Cystic Fibrosis
Cell Movement
Cell Differentiation
Epithelium
Phosphorylation
Cytokines
Calcium
Water
Wounds and Injuries
Growth
Infection

Keywords

  • β-Agonists
  • Airway epithelium
  • Calcium
  • Cyclic adenosine monophosphate
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Effects of β-agonists on airway epithelial cells. / Salathe, Matthias A.

In: Journal of Allergy and Clinical Immunology, Vol. 110, No. 6 SUPPL., 01.12.2002.

Research output: Contribution to journalArticle

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