Effector protein modulation of host cells: examples in the Chlamydia spp. arsenal

Helen J. Betts, Katerina Wolf, Kenneth A. Fields

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

As obligate intracellular parasites, Chlamydia spp. must create and maintain a specialized intracellular niche while simultaneously contending with potent host defenses. Discoveries that chlamydiae deploy an array of anti-host proteins have placed new emphasis on deciphering the impact of host cell biology on chlamydial development and virulence. Recent advances in the understanding of chlamydial pathogenesis are exemplified by work describing potential roles of (i) chlamydial Tarp in invasion, (ii) Inc proteins in modulation of vesicular interactions, and (iii) chlamydial proteins in disregulation of NF-κB signal transduction. Characterization of these chlamydial effector proteins promises to answer old questions and reveals previously unappreciated biology. The challenge will be to determine how these molecular mechanisms mesh together and collectively contribute to Chlamydia-mediated disease.

Original languageEnglish (US)
Pages (from-to)81-87
Number of pages7
JournalCurrent Opinion in Microbiology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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