Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With Epilepsy

Rafal D. Mazur, Qianyu Wang, BA, Kenneth Kato, BS, Richard Buchsbaum, BS, Jennifer Bonito, BS, Hyunmi Choi, Lawrence Hirsch, Kamil Detyniecki

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The main objective of this study was to assess the efficacy, safety, and retention rates of levetiracetam monotherapy in children with epilepsy. A retrospective review of pediatric patients receiving levetiracetam monotherapy at 2 large tertiary epilepsy centers over an 11-year period was conducted. One hundred two patients using levetiracetam monotherapy with a mean age of 13.1 years were identified. For the entire cohort, a 6-month retention rate was 61.1% and a 12-month retention rate 53.1%. With regard to seizure freedom, 46.8% of those patients that remained on monotherapy for at least 6 months became seizure free. Twelve-month seizure freedom was reached by 41.2%. About one-third (32.4%) of patients reported adverse effects, with irritability, moodiness, and depression being the most common. Despite a number of patients that reported adverse events, levetiracetam monotherapy was found to be potentially effective in this cohort of children with epilepsy and warrants further, prospective studies.

Original languageEnglish (US)
Pages (from-to)593-597
Number of pages5
JournalJournal of child neurology
Volume34
Issue number10
DOIs
StatePublished - Sep 1 2019
Externally publishedYes

Keywords

  • antiepileptic drug
  • efficacy
  • epilepsy
  • levetiracetam
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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