Effectiveness of a gentamicin dosing protocol based on postconceptional age: Comparison to published neonatal guidelines

A. M. Lopez-Samblas, C. L. Torres, H. Wang, William J Feuer, R. N. Goldberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the effectiveness of a gentamicin dosing protocol based on postconceptional age in producing therapeutic serum concentrations and to compare the protocol with commonly used gentamicin dosing guidelines. DESIGN: During the initial three months of this study infants were dosed according to physician discretion (group I). In the subsequent three-month period patients were dosed according to a post-conceptional age dosing schedule (group II). SETTING: Infants were enrolled after being admitted to the Newborn Intensive Care Unit at the University of Miami/Jackson Memorial Medical Center. PATIENTS: Infants less than 37 weeks gestational age with normal renal function, not receiving indomethacin, and requiring gentamicin treatment were enrolled. Fifty-nine infants were enrolled into group I (median weight 1300 g [range 720-3300]), postconceptional age 29 weeks [26- 37]); and 68 infants were enrolled into group II (weight 970 g [530-3000], postconceptional age 29 weeks [24-36]). INTERVENTION: Patients in group II were dosed according to the following protocol: postconceptional age

Original languageEnglish (US)
Pages (from-to)534-538
Number of pages5
JournalAnnals of Pharmacotherapy
Volume26
Issue number4
StatePublished - 1992

Fingerprint

Gentamicins
Guidelines
Weights and Measures
Neonatal Intensive Care Units
Indomethacin
Gestational Age
Appointments and Schedules
Physicians
Kidney
Therapeutics
Serum

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lopez-Samblas, A. M., Torres, C. L., Wang, H., Feuer, W. J., & Goldberg, R. N. (1992). Effectiveness of a gentamicin dosing protocol based on postconceptional age: Comparison to published neonatal guidelines. Annals of Pharmacotherapy, 26(4), 534-538.

Effectiveness of a gentamicin dosing protocol based on postconceptional age : Comparison to published neonatal guidelines. / Lopez-Samblas, A. M.; Torres, C. L.; Wang, H.; Feuer, William J; Goldberg, R. N.

In: Annals of Pharmacotherapy, Vol. 26, No. 4, 1992, p. 534-538.

Research output: Contribution to journalArticle

Lopez-Samblas, AM, Torres, CL, Wang, H, Feuer, WJ & Goldberg, RN 1992, 'Effectiveness of a gentamicin dosing protocol based on postconceptional age: Comparison to published neonatal guidelines', Annals of Pharmacotherapy, vol. 26, no. 4, pp. 534-538.
Lopez-Samblas, A. M. ; Torres, C. L. ; Wang, H. ; Feuer, William J ; Goldberg, R. N. / Effectiveness of a gentamicin dosing protocol based on postconceptional age : Comparison to published neonatal guidelines. In: Annals of Pharmacotherapy. 1992 ; Vol. 26, No. 4. pp. 534-538.
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