'Effective inefficiency': Cellular control of protein trafficking as a mechanism of post-translational regulation

P. Michael Conn, Jo Ann Janovick, Shaun P. Brothers, Paul E. Knollman

Research output: Contribution to journalComment/debate

32 Scopus citations

Abstract

The great writer and polyglot, W Somerset Maugham said, 'I'll give you my opinion of the human race in a nutshell...their heart's in the right place, but their head is a thoroughly inefficient organ.' If his words are applied to trafficking of the human pituitary gonadotropin-releasing hormone receptor, it turns out that he was more right than he knew. Paradoxically, the inefficiency of receptor trafficking to the plasma membrane can bring regulatory advantages to cells. Understanding the mechanism by which cells recognize correctly folded proteins in health and disease opens doors to new therapeutic approaches and provides a more accurate view of mechanisms of normal cell function than is presently available.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalJournal of Endocrinology
Volume190
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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