Effect on renal function of change from high to moderate protein intake in type I diabetic patients

Warren Kupin, P. Cortes, F. Dumler, C. S. Feldkamp, M. C. Kilates, N. W. Levin

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The effects on renal function of moderate restriction in protein intake were studied in 14- to 20-yr-old type I diabetic patients who had no clinical renal disease or hypertension; matched normal subjects served as controls. After assessment of protein intake and renal function, studies were conducted at the completion of each of two consecutive dietary periods of 1 wk. Diets containing 3.5 and 1.5 g·kg-1·day-1 protein were provided during the first and second periods, respectively. Baseline protein intakes were substantial in both controls (1.86 g·kg-1·day-1) and diabetics (2.17 g·kg-1·day -1). Baseline creatinine clearance was increased in diabetics (P=.043). At the end of the high-protein intake period, both diabetics and controls showed similar high values of glomerular filtration rate (GFR) and renal plasma flow (RPF). GFR and RPF decreased markedly (P<.001) and to a similar degree in both groups after normal protein intake. GFR and RPF in diabetics were not higher than in controls at this point, but filtration fraction was increased in diabetics. Albumin excretion rates were similar in both groups and not influenced by renal function changes. GFR and RPF values correlated significantly with the quantity of protein intake, as estimated from the urea nitrogen appearance rate in both groups. The results suggest that the functional response to variations in protein intake is not altered in the diabetic kidney. In addition, increased renal function in diabetics may be related partly to the excessive protein content in commonly prescribed diabetic diets. Moderate dietary protein restriction in an additional approach for the correction of diabetic hyperfiltration.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalDiabetes
Volume36
Issue number1
StatePublished - Dec 1 1987
Externally publishedYes

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Renal Plasma Flow
Kidney
Glomerular Filtration Rate
Proteins
Period Circadian Proteins
Diabetic Diet
Dietary Proteins
Urea
Albumins
Creatinine
Nitrogen
Diet
Hypertension

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Kupin, W., Cortes, P., Dumler, F., Feldkamp, C. S., Kilates, M. C., & Levin, N. W. (1987). Effect on renal function of change from high to moderate protein intake in type I diabetic patients. Diabetes, 36(1), 73-79.

Effect on renal function of change from high to moderate protein intake in type I diabetic patients. / Kupin, Warren; Cortes, P.; Dumler, F.; Feldkamp, C. S.; Kilates, M. C.; Levin, N. W.

In: Diabetes, Vol. 36, No. 1, 01.12.1987, p. 73-79.

Research output: Contribution to journalArticle

Kupin, W, Cortes, P, Dumler, F, Feldkamp, CS, Kilates, MC & Levin, NW 1987, 'Effect on renal function of change from high to moderate protein intake in type I diabetic patients', Diabetes, vol. 36, no. 1, pp. 73-79.
Kupin W, Cortes P, Dumler F, Feldkamp CS, Kilates MC, Levin NW. Effect on renal function of change from high to moderate protein intake in type I diabetic patients. Diabetes. 1987 Dec 1;36(1):73-79.
Kupin, Warren ; Cortes, P. ; Dumler, F. ; Feldkamp, C. S. ; Kilates, M. C. ; Levin, N. W. / Effect on renal function of change from high to moderate protein intake in type I diabetic patients. In: Diabetes. 1987 ; Vol. 36, No. 1. pp. 73-79.
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