Effect of ultraviolet radiation—induced inflammation on epidermal wound healing

Mark R. Kaiser, Stephen C Davis, Patricia M. Mertz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To examine the influence of ultraviolet radiation, a potent inducer of interleukin‐1 and other growth factors, on the rate of epidermal migration, we used a porcine model of wound healing. Wounds were treated in one of the following treatment groups: (1) two minimal erythema doses of ultraviolet radiation once daily for 2 days before wounding, (2) two minimal erythema doses of ultraviolet radiation once daily for 2 days before wounding followed with continuous treatment until all wounds were 100% epithelized, (3) or no ultraviolet radiation treatment until healing was complete. Using a macroscopic salt‐split technique, we examined epidermal specimens macroscopically for epithelialization. Treatment both before and after ultraviolet radiation significantly enhanced epithelialization when compared with non‐ultraviolet radiation‐treated control wounds. These experiments show that ultraviolet radiation treatment can augment the rate of healing of partial‐thickness wounds.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalWound Repair and Regeneration
Volume3
Issue number3
DOIs
StatePublished - 1995

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ASJC Scopus subject areas

  • Surgery
  • Dermatology

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