Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader, R. T. Turner, Guy Howard, D. J. Baylink

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalMetabolic Bone Disease and Related Research
Volume1
Issue number4
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Calcifediol
Calcium
Bone and Bones
Diet
Calcitriol
Phosphorus
Bone Matrix
Osteogenesis
Kidney

Keywords

  • 1,25-dihydroxyvitamin D
  • 25-hydroxyvitamin D
  • Mineral metabolism
  • Parathyroid extract
  • Quantitative histology
  • Thyroparathyroidectomy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery

Cite this

Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats. / Rader, J. I.; Turner, R. T.; Howard, Guy; Baylink, D. J.

In: Metabolic Bone Disease and Related Research, Vol. 1, No. 4, 01.01.1979, p. 313-317.

Research output: Contribution to journalArticle

@article{089d958a3c6441a4964e82412a5af768,
title = "Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats",
abstract = "Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1{\%} calcium, 0.6{\%} phosphorus (low calcium), or 0.6{\%} calcium, 0.6{\%} phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.",
keywords = "1,25-dihydroxyvitamin D, 25-hydroxyvitamin D, Mineral metabolism, Parathyroid extract, Quantitative histology, Thyroparathyroidectomy",
author = "Rader, {J. I.} and Turner, {R. T.} and Guy Howard and Baylink, {D. J.}",
year = "1979",
month = "1",
day = "1",
doi = "10.1016/0221-8747(79)90025-0",
language = "English",
volume = "1",
pages = "313--317",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

AU - Rader, J. I.

AU - Turner, R. T.

AU - Howard, Guy

AU - Baylink, D. J.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

AB - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

KW - 1,25-dihydroxyvitamin D

KW - 25-hydroxyvitamin D

KW - Mineral metabolism

KW - Parathyroid extract

KW - Quantitative histology

KW - Thyroparathyroidectomy

UR - http://www.scopus.com/inward/record.url?scp=49249153110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49249153110&partnerID=8YFLogxK

U2 - 10.1016/0221-8747(79)90025-0

DO - 10.1016/0221-8747(79)90025-0

M3 - Article

AN - SCOPUS:49249153110

VL - 1

SP - 313

EP - 317

JO - Bone

JF - Bone

SN - 8756-3282

IS - 4

ER -