Abstract
Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.
| Original language | English |
|---|---|
| Pages (from-to) | 313-317 |
| Number of pages | 5 |
| Journal | Metabolic Bone Disease and Related Research |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1979 |
| Externally published | Yes |
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Keywords
- 1,25-dihydroxyvitamin D
- 25-hydroxyvitamin D
- Mineral metabolism
- Parathyroid extract
- Quantitative histology
- Thyroparathyroidectomy
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Surgery
Cite this
Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats. / Rader, J. I.; Turner, R. T.; Howard, Guy; Baylink, D. J.
In: Metabolic Bone Disease and Related Research, Vol. 1, No. 4, 01.01.1979, p. 313-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats
AU - Rader, J. I.
AU - Turner, R. T.
AU - Howard, Guy
AU - Baylink, D. J.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.
AB - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.
KW - 1,25-dihydroxyvitamin D
KW - 25-hydroxyvitamin D
KW - Mineral metabolism
KW - Parathyroid extract
KW - Quantitative histology
KW - Thyroparathyroidectomy
UR - http://www.scopus.com/inward/record.url?scp=49249153110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49249153110&partnerID=8YFLogxK
U2 - 10.1016/0221-8747(79)90025-0
DO - 10.1016/0221-8747(79)90025-0
M3 - Article
AN - SCOPUS:49249153110
VL - 1
SP - 313
EP - 317
JO - Bone
JF - Bone
SN - 8756-3282
IS - 4
ER -