Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader; R. T. Turner; G. A. Howard; D. J. Baylink

doi:10.1016/0221-8747(79)90025-0

Effect of treatment with parathyroid extract on bone parameters and metabolism of ³H-25-hydroxyvitamin D₃ in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader, R. T. Turner, G. A. Howard, D. J. Baylink

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D₃ to 1,25-dihydroxyvitamin D₃ was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D₃ was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

Original language	English (US)
Pages (from-to)	313-317
Number of pages	5
Journal	Metabolic Bone Disease and Related Research
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0221-8747(79)90025-0
State	Published - 1979
Externally published	Yes

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Keywords

1,25-dihydroxyvitamin D
25-hydroxyvitamin D
Mineral metabolism
Parathyroid extract
Quantitative histology
Thyroparathyroidectomy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Surgery

Cite this

Rader, J. I., Turner, R. T., Howard, G. A., & Baylink, D. J. (1979). Effect of treatment with parathyroid extract on bone parameters and metabolism of ³H-25-hydroxyvitamin D₃ in Hypocalcemic Thyroparathyroidectomized Rats. Metabolic Bone Disease and Related Research, 1(4), 313-317. https://doi.org/10.1016/0221-8747(79)90025-0

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abstract = "Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.",

keywords = "1,25-dihydroxyvitamin D, 25-hydroxyvitamin D, Mineral metabolism, Parathyroid extract, Quantitative histology, Thyroparathyroidectomy",

author = "Rader, {J. I.} and Turner, {R. T.} and Howard, {G. A.} and Baylink, {D. J.}",

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AU - Baylink, D. J.

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N2 - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

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10.1016/0221-8747(79)90025-0