Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader; R. T. Turner; G. A. Howard; D. J. Baylink

doi:10.1016/0221-8747(79)90025-0

Effect of treatment with parathyroid extract on bone parameters and metabolism of ³H-25-hydroxyvitamin D₃ in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader, R. T. Turner, G. A. Howard, D. J. Baylink

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D₃ to 1,25-dihydroxyvitamin D₃ was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D₃ was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

Original language	English (US)
Pages (from-to)	313-317
Number of pages	5
Journal	Metabolic Bone Disease and Related Research
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0221-8747(79)90025-0
State	Published - 1979
Externally published	Yes

Keywords

1,25-dihydroxyvitamin D
25-hydroxyvitamin D
Mineral metabolism
Parathyroid extract
Quantitative histology
Thyroparathyroidectomy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Surgery

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10.1016/0221-8747(79)90025-0

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@article{089d958a3c6441a4964e82412a5af768,

title = "Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats",

abstract = "Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.",

keywords = "1,25-dihydroxyvitamin D, 25-hydroxyvitamin D, Mineral metabolism, Parathyroid extract, Quantitative histology, Thyroparathyroidectomy",

author = "Rader, {J. I.} and Turner, {R. T.} and Howard, {G. A.} and Baylink, {D. J.}",

note = "Funding Information: Acknowledgements: Supported in part by NIH grants AG 00299 and DE 02600, and the Research Service of the Veterans Administration.",

year = "1979",

doi = "10.1016/0221-8747(79)90025-0",

language = "English (US)",

volume = "1",

pages = "313--317",

journal = "Bone",

issn = "8756-3282",

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number = "4",

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T1 - Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

AU - Rader, J. I.

AU - Turner, R. T.

AU - Howard, G. A.

AU - Baylink, D. J.

N1 - Funding Information: Acknowledgements: Supported in part by NIH grants AG 00299 and DE 02600, and the Research Service of the Veterans Administration.

PY - 1979

Y1 - 1979

N2 - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

AB - Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

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KW - Mineral metabolism

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KW - Quantitative histology

KW - Thyroparathyroidectomy

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