Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats

J. I. Rader, R. T. Turner, G. A. Howard, D. J. Baylink

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Thyroparathyroidectomized (TPTX) rats fed diets containing 0.1% calcium, 0.6% phosphorus (low calcium), or 0.6% calcium, 0.6% phosphorus (normal calcium) become hypocalcemic and hyperphosphatemic. Inhibitory effects of parathyroid extract (PTE; 20 Units/100 g twice daily, 8-9 days) on rates of bone formation, matrix apposition, and osteoid maturation were observed in TPTX rats fed the low calcium diet, but not in those fed the normal calcium diet. Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 was increased in response to PTE only in TPTX rats fed the normal calcium diet. In this group increased formation of 1,25-dihydroxyvitamin D3 was associated with a significant reduction in the width of the mineralizing front. Our results indicate that serum calcium plays an important role in modulating the effect of PTE on metabolic processes in bone and kidney.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalMetabolic Bone Disease and Related Research
Volume1
Issue number4
DOIs
StatePublished - 1979
Externally publishedYes

Keywords

  • 1,25-dihydroxyvitamin D
  • 25-hydroxyvitamin D
  • Mineral metabolism
  • Parathyroid extract
  • Quantitative histology
  • Thyroparathyroidectomy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery

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