Effect of thyrotropin (TSH)-releasing factor (TRF) on plasma TSH levels in nutria (Myocastor coypus)

T. W. Redding, Z. Itoh, Andrew V Schally

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intrapituitary or intracarotid infusion of porcine thyrotropin-releasing factor (TRF) into coypu (nutria) failed to increase plasma thyrotropin (TSH) levels. Intravenous administration of TRF into thyroidectomized nutria resulted in an increase in plasma TSH, but the responses were inconsistent. The increase in plasma TSH after TRF was readily demonstrable when thyroidectomized nutria were pretreated with small doses of triiodothyronine. Low sensitivity of the nutria to exogenous TRF may be ascribed, in part, to the relatively low TSH levels in the anterior pituitary gland. These studies nevertheless indicate that TRF can increase plasma TSH levels in the nutria and extend to one more species the evidence of responsiveness to TRF.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalGeneral and Comparative Endocrinology
Volume12
Issue number2
StatePublished - Apr 1 1969
Externally publishedYes

Fingerprint

Myocastor coypus
thyrotropin
Thyrotropin-Releasing Hormone
Anterior Pituitary Gland
Triiodothyronine
Thyrotropin
Intravenous Administration
anterior pituitary
Swine
triiodothyronine
intravenous injection
swine
dosage

ASJC Scopus subject areas

  • Endocrinology

Cite this

Effect of thyrotropin (TSH)-releasing factor (TRF) on plasma TSH levels in nutria (Myocastor coypus). / Redding, T. W.; Itoh, Z.; Schally, Andrew V.

In: General and Comparative Endocrinology, Vol. 12, No. 2, 01.04.1969, p. 391-394.

Research output: Contribution to journalArticle

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