Abstract
Intrapituitary or intracarotid infusion of porcine thyrotropin-releasing factor (TRF) into coypu (nutria) failed to increase plasma thyrotropin (TSH) levels. Intravenous administration of TRF into thyroidectomized nutria resulted in an increase in plasma TSH, but the responses were inconsistent. The increase in plasma TSH after TRF was readily demonstrable when thyroidectomized nutria were pretreated with small doses of triiodothyronine. Low sensitivity of the nutria to exogenous TRF may be ascribed, in part, to the relatively low TSH levels in the anterior pituitary gland. These studies nevertheless indicate that TRF can increase plasma TSH levels in the nutria and extend to one more species the evidence of responsiveness to TRF.
| Original language | English |
|---|---|
| Pages (from-to) | 391-394 |
| Number of pages | 4 |
| Journal | General and Comparative Endocrinology |
| Volume | 12 |
| Issue number | 2 |
| State | Published - Apr 1 1969 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Effect of thyrotropin (TSH)-releasing factor (TRF) on plasma TSH levels in nutria (Myocastor coypus). / Redding, T. W.; Itoh, Z.; Schally, Andrew V.
In: General and Comparative Endocrinology, Vol. 12, No. 2, 01.04.1969, p. 391-394.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of thyrotropin (TSH)-releasing factor (TRF) on plasma TSH levels in nutria (Myocastor coypus)
AU - Redding, T. W.
AU - Itoh, Z.
AU - Schally, Andrew V
PY - 1969/4/1
Y1 - 1969/4/1
N2 - Intrapituitary or intracarotid infusion of porcine thyrotropin-releasing factor (TRF) into coypu (nutria) failed to increase plasma thyrotropin (TSH) levels. Intravenous administration of TRF into thyroidectomized nutria resulted in an increase in plasma TSH, but the responses were inconsistent. The increase in plasma TSH after TRF was readily demonstrable when thyroidectomized nutria were pretreated with small doses of triiodothyronine. Low sensitivity of the nutria to exogenous TRF may be ascribed, in part, to the relatively low TSH levels in the anterior pituitary gland. These studies nevertheless indicate that TRF can increase plasma TSH levels in the nutria and extend to one more species the evidence of responsiveness to TRF.
AB - Intrapituitary or intracarotid infusion of porcine thyrotropin-releasing factor (TRF) into coypu (nutria) failed to increase plasma thyrotropin (TSH) levels. Intravenous administration of TRF into thyroidectomized nutria resulted in an increase in plasma TSH, but the responses were inconsistent. The increase in plasma TSH after TRF was readily demonstrable when thyroidectomized nutria were pretreated with small doses of triiodothyronine. Low sensitivity of the nutria to exogenous TRF may be ascribed, in part, to the relatively low TSH levels in the anterior pituitary gland. These studies nevertheless indicate that TRF can increase plasma TSH levels in the nutria and extend to one more species the evidence of responsiveness to TRF.
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UR - http://www.scopus.com/inward/citedby.url?scp=0014493308&partnerID=8YFLogxK
M3 - Article
VL - 12
SP - 391
EP - 394
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
SN - 0016-6480
IS - 2
ER -