Effect of thyrotropin releasing hormone (TRH) on the menstrual cycle in women

Arturo Zarate, Andrew V. Schally, Jorge Soria, Lawrence S. Jacobs, Elias S. Canales

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Thyrotropin releasing hormone (TRH) was given to 6 women for 8 consecutive days beginning between Days 8 and 9 of the menstrual cycle. Daily serum samples were obtained for radioimmunoassay for luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) secretory response. Thyrotropin releasing hormone was ineffective in interfering with ovulation and failed to show significant effects on cycle lengths. Moreover, the length of the luteal phase was not affected by TRH, as demonstrated by basal body temperature, endometrial biopsy, and pregnanediol excretion. These results arc in disagreement with recent findings in baboons receiving TRH. This study also demonstrated that TRH administration induces a prolactin secretory response which blocks neither the LH surge nor the ovarian rcspnsiveness to endogenous gonadotropins in women who menstruate normally

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalObstetrics and gynecology
Issue number4
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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