Effect of thyrotropin-releasing hormone on gastro-intestinal secretions in dogs

Stanislaw J. Konturek, Jolanta Jaworek, Marek Cieszkowski, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Thyrotropin-releasing hormone (TRH) immunoreactivity has been shown previously to be distributed throughout the gastrointestinal tract and the pancreas. This study demonstrated that TRH given intravenously suppresses, in a dose-related manner, sham-feeding induced food intake and inhibits gastric secretion provoked by infusion of pentagastrin or instillation of 10% liver extract into the stomach. TRH also reduces pancreatic response to secretin, caerulein, feeding a meat meal or duodenal acidification. The findings that TRH inhibits gastric and pancreatic secretions induced by exogenous and endogenous stimulants, and that the inhibition by TRH of post-prandial secretion is not accompanied by any change in serum gastrin, indicate that TRH probably acts directly on the exocrine stomach and pancreas.

Original languageEnglish (US)
Pages (from-to)2289-2298
Number of pages10
JournalLife Sciences
Issue number22
StatePublished - Nov 30 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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