Effect of thyroid hormone on growth: Lessons from the syndrome of resistance to thyroid hormone

R. E. Weiss, S. Refetoff

Research output: Contribution to journalArticle

69 Scopus citations


Thyroid hormone deprivation results in deleterious effects on bone growth. The delayed bone development is mediated by a direct effect of thyroid hormone on bone and an indirect effect of the hormone on GH release and IGF-1 action. Both TRα and TPβ are expressed in bone cells. To examine the role of TRβ on bone, we have reviewed the growth abnormalities in the human syndrome of RTH caused by mutations in the TRβ gene. The mutant TRβ reduces the tissue responsiveness to thyroid hormone, producing in some tissues variable degrees of thyroid hormone deprivation. With regard to bone, relative thyroid hormone deficiency caused by the mutant TRβ produces short stature and delayed bone growth but does not attenuate growth to the extent that absolute thyroid hormone deficiency does. These observations indicate that an intact TRβ is required for normal bone development and growth.

Original languageEnglish (US)
Pages (from-to)719-730
Number of pages12
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
StatePublished - Jan 1 1996
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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