Effect of Theophylline on the Proportion and Function of T‐Suppressor Cells in Asthmatic Children

N. Lahat, E. Nir, L. Horenstien, A. A. Colin

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.

Original languageEnglish (US)
Pages (from-to)453-457
Number of pages5
JournalAllergy
Volume40
Issue number6
DOIs
StatePublished - Aug 1985

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Keywords

  • asthma
  • suppressor T‐cells
  • theophylline. Accepted for publication 15 March 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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