Effect of Theophylline on the Proportion and Function of T‐Suppressor Cells in Asthmatic Children

N. Lahat; E. Nir; L. Horenstien; A. A. Colin

doi:10.1111/j.1398-9995.1985.tb02685.x

Effect of Theophylline on the Proportion and Function of T‐Suppressor Cells in Asthmatic Children

N. Lahat, E. Nir, L. Horenstien, A. A. Colin

Pediatrics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.

Original language	English (US)
Pages (from-to)	453-457
Number of pages	5
Journal	Allergy
Volume	40
Issue number	6
DOIs	https://doi.org/10.1111/j.1398-9995.1985.tb02685.x
State	Published - Aug 1985

Keywords

asthma
suppressor T‐cells
theophylline. Accepted for publication 15 March 1985

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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AU - Nir, E.

AU - Horenstien, L.

AU - Colin, A. A.

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AB - T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.

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KW - suppressor T‐cells

KW - theophylline. Accepted for publication 15 March 1985

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