Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children

N. Lahat, E. Nir, L. Horenstien, Andrew Colin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline-sensitive T-suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline-free medium, the proportion of theophylline-sensitive T-cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume40
Issue number6
StatePublished - Dec 1 1985
Externally publishedYes

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Theophylline
T-Lymphocytes
Blood Cells
Reference Values
Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children. / Lahat, N.; Nir, E.; Horenstien, L.; Colin, Andrew.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 40, No. 6, 01.12.1985, p. 453-457.

Research output: Contribution to journalArticle

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