Effect of the infusion of pGlu-His-D-Ala-OH on pancreatic secretion in obese subjects

A. L. Calle-Pascual, C. Rodriguez, E. Yuste, J. M. De Matias, A. L. Charro, I. Carretero, B. Garcia, Renzhi Cai, A. V. Schally

Research output: Contribution to journalArticle

Abstract

The effects of intravenous infusion of pGlu-His-D-Ala-OH, an analog of the postulated anorexigenic peptide pGlu-His-Gly-OH, on the pancreatic response to the oral ingestion of 75 g of glucose were evaluated in 6 obese subjects. The infusion of the analog significantly reduced the serum insulin response to the oral ingestion of glucose (p < 0.05), but did not modify the levels of C-peptide, gastrin, glucose or serum amylases. Similarly, the area under the curve, which represents the insulin response to the oral ingestion of glucose was reduced from 35,303 ± 7,061 to 20,590 ± 2,286 pmol/min/l; p < 0.05. The smaller rise in serum insulin was associated with a greater hepatic insulin extraction, measured in terms of the molar ratio of the C-peptide to insulin, from 76.06 ± 2.4% vs 88.62 ± 1.71%; p < 0.05. However, there was no decrease in the pancreatic insulin secretion, measured as the C-peptide levels. These results demonstrate that the infusion of the anorexigenic peptide analog improves hepatic insulin extraction in obese subjects. Its therapeutic application in obesity remains to be determined.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume4
Issue number2
StatePublished - Jul 31 1991
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Effect of the infusion of pGlu-His-D-Ala-OH on pancreatic secretion in obese subjects'. Together they form a unique fingerprint.

  • Cite this

    Calle-Pascual, A. L., Rodriguez, C., Yuste, E., De Matias, J. M., Charro, A. L., Carretero, I., Garcia, B., Cai, R., & Schally, A. V. (1991). Effect of the infusion of pGlu-His-D-Ala-OH on pancreatic secretion in obese subjects. Diabetes, Nutrition and Metabolism - Clinical and Experimental, 4(2), 129-133.