Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

V. V. Solovyeva; K. G. Kolobynina; M. O. Gomzikova; L. G. Tazetdinova; M. N. Zhuravleva; Vladlen Z Slepak; A. A. Rizvanov

Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

V. V. Solovyeva, K. G. Kolobynina, M. O. Gomzikova, L. G. Tazetdinova, M. N. Zhuravleva, Vladlen Z Slepak, A. A. Rizvanov

Molecular and Cellular Pharmacology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.

Original language	English (US)
Pages (from-to)	90-93
Number of pages	4
Journal	Genes and Cells
Volume	10
Issue number	4
State	Published - Dec 1 2015

Keywords

Immunophenotype
Mesenchymal stem cells
Osteogenesis
Osteogenic differentiation
Recombinant lentiviruses
Tescalcin

ASJC Scopus subject areas

Biotechnology
Cell Biology
Molecular Biology
Biomedical Engineering
Surgery
Transplantation

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title = "Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells",

abstract = "Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.",

keywords = "Immunophenotype, Mesenchymal stem cells, Osteogenesis, Osteogenic differentiation, Recombinant lentiviruses, Tescalcin",

author = "Solovyeva, {V. V.} and Kolobynina, {K. G.} and Gomzikova, {M. O.} and Tazetdinova, {L. G.} and Zhuravleva, {M. N.} and Slepak, {Vladlen Z} and Rizvanov, {A. A.}",

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AU - Solovyeva, V. V.

AU - Kolobynina, K. G.

AU - Gomzikova, M. O.

AU - Tazetdinova, L. G.

AU - Zhuravleva, M. N.

AU - Slepak, Vladlen Z

AU - Rizvanov, A. A.

PY - 2015/12/1

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N2 - Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.

AB - Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.

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KW - Mesenchymal stem cells

KW - Osteogenesis

KW - Osteogenic differentiation

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