Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

V. V. Solovyeva, K. G. Kolobynina, M. O. Gomzikova, L. G. Tazetdinova, M. N. Zhuravleva, Vladlen Z Slepak, A. A. Rizvanov

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.

Original languageEnglish (US)
Pages (from-to)90-93
Number of pages4
JournalGenes and Cells
Volume10
Issue number4
StatePublished - Dec 1 2015

Keywords

  • Immunophenotype
  • Mesenchymal stem cells
  • Osteogenesis
  • Osteogenic differentiation
  • Recombinant lentiviruses
  • Tescalcin

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology
  • Biomedical Engineering
  • Surgery
  • Transplantation

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  • Cite this

    Solovyeva, V. V., Kolobynina, K. G., Gomzikova, M. O., Tazetdinova, L. G., Zhuravleva, M. N., Slepak, V. Z., & Rizvanov, A. A. (2015). Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells. Genes and Cells, 10(4), 90-93.