Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells

V. V. Solovyeva, K. G. Kolobynina, M. O. Gomzikova, L. G. Tazetdinova, M. N. Zhuravleva, Vladlen Z Slepak, A. A. Rizvanov

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tescalcin plays an important role in the proliferation and differentiation of certain cell types. It is involved in the signaling pathways of mitogen-activated protein kinase and is reported to directly interact with subunit 4 of COP9 signalosome and Na/H exchanger NHE1. Since tescalcin is one of the factors that allow one type of progenitor cells differentiate into a variety of specialized cell types, it can be a potential molecular tool for modulation of phenotype of target cells. The ability of adipose-derived mesenchymal stem cells (ADSCs) to differentiate into osteogenic direction makes them a promising adult stem cell type for regenerative medicine and tissue engineering. Here we show that ADSCs with tescalcin overexpression had a significantly higher level of matrix mineralization compared with control ADSCs. This finding indicates that ectopic tescalcin overexpression might affect osteogenic differentiation of ADSCs.

Original languageEnglish (US)
Pages (from-to)90-93
Number of pages4
JournalGenes and Cells
Volume10
Issue number4
StatePublished - Dec 1 2015

Fingerprint

Stem cells
Mesenchymal Stromal Cells
Sodium-Hydrogen Antiporter
Adult Stem Cells
Regenerative Medicine
Tissue Engineering
Mitogen-Activated Protein Kinases
Cell Differentiation
Stem Cells
Tissue engineering
Phenotype
Cells
Modulation
Proteins

Keywords

  • Immunophenotype
  • Mesenchymal stem cells
  • Osteogenesis
  • Osteogenic differentiation
  • Recombinant lentiviruses
  • Tescalcin

ASJC Scopus subject areas

  • Biotechnology
  • Cell Biology
  • Molecular Biology
  • Biomedical Engineering
  • Surgery
  • Transplantation

Cite this

Solovyeva, V. V., Kolobynina, K. G., Gomzikova, M. O., Tazetdinova, L. G., Zhuravleva, M. N., Slepak, V. Z., & Rizvanov, A. A. (2015). Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells. Genes and Cells, 10(4), 90-93.

Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells. / Solovyeva, V. V.; Kolobynina, K. G.; Gomzikova, M. O.; Tazetdinova, L. G.; Zhuravleva, M. N.; Slepak, Vladlen Z; Rizvanov, A. A.

In: Genes and Cells, Vol. 10, No. 4, 01.12.2015, p. 90-93.

Research output: Contribution to journalArticle

Solovyeva, VV, Kolobynina, KG, Gomzikova, MO, Tazetdinova, LG, Zhuravleva, MN, Slepak, VZ & Rizvanov, AA 2015, 'Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells', Genes and Cells, vol. 10, no. 4, pp. 90-93.
Solovyeva VV, Kolobynina KG, Gomzikova MO, Tazetdinova LG, Zhuravleva MN, Slepak VZ et al. Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells. Genes and Cells. 2015 Dec 1;10(4):90-93.
Solovyeva, V. V. ; Kolobynina, K. G. ; Gomzikova, M. O. ; Tazetdinova, L. G. ; Zhuravleva, M. N. ; Slepak, Vladlen Z ; Rizvanov, A. A. / Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells. In: Genes and Cells. 2015 ; Vol. 10, No. 4. pp. 90-93.
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