Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: A PRoFESS subgroup analysis

Philip M.W. Bath, Reneé H. Martin, Yuko Palesch, Daniel Cotton, Salim Yusuf, Ralph Sacco, Hans Christoph Diener, Danilo Toni, Conrado Estol, Robin Roberts

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

BACKGROUND AND PURPOSE-: High blood pressure (BP) is common in acute ischemic stroke and associated independently with a poor functional outcome. However, the management of BP acutely remains unclear because no large trials have been completed. METHODS-: The factorial PRoFESS secondary stroke prevention trial assessed BP-lowering and antiplatelet strategies in 20 332 patients; 1360 were enrolled within 72 hours of ischemic stroke, with telmisartan (angiotensin receptor antagonist, 80 mg/d, n=647) vs placebo (n=713). For this nonprespecified subgroup analysis, the primary outcome was functional outcome at 30 days; secondary outcomes included death, recurrence, and hemodynamic measures at up to 90 days. Analyses were adjusted for baseline prognostic variables and antiplatelet assignment. RESULTS-: Patients were representative of the whole trial (age 67 years, male 65%, baseline BP 147/84 mm Hg, small artery disease 60%, NIHSS 3) and baseline variables were similar between treatment groups. The mean time from stroke to recruitment was 58 hours. Combined death or dependency (modified Rankin scale: OR, 1.03; 95% CI, 0.84-1.26; P=0.81; death: OR, 1.05; 95% CI, 0.27-4.04; and stroke recurrence: OR, 1.40; 95% CI, 0.68-2.89; P=0.36) did not differ between the treatment groups. In comparison with placebo, telmisartan lowered BP (141/82 vs 135/78 mm Hg, difference 6 to 7 mm Hg and 2 to 4 mm Hg; P<0.001), pulse pressure (3 to 4 mm Hg; P<0.002), and rate-pressure product (466 mm Hg.bpm; P=0.0004). CONCLUSION-: Treatment with telmisartan in 1360 patients with acute mild ischemic stroke and mildly elevated BP appeared to be safe with no excess in adverse events, was not associated with a significant effect on functional dependency, death, or recurrence, and modestly lowered BP.

Original languageEnglish (US)
Pages (from-to)3541-3546
Number of pages6
JournalStroke
Volume40
Issue number11
DOIs
StatePublished - Nov 2009

Keywords

  • Acute stroke
  • Blood pressure
  • Ischemic stroke
  • Outcome
  • Randomized controlled trial
  • Telmisartan

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Fingerprint Dive into the research topics of 'Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: A PRoFESS subgroup analysis'. Together they form a unique fingerprint.

Cite this