Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in two brothers with hypogonadotropic hypogonadism and anosmia

Arturo Zárate, Abba J. Kastin, Jorge Soria, Elias S. Canales, Andrew V. Schally

Research output: Contribution to journalArticle

36 Scopus citations


Two brothers with hypogonadotropic hypogonadism, cryptorchism and anosmia were given synthetic LH-releasing hormone (LHRH) by a single intravenous injection and serum levels of FSH and LH were measured by radioimmunoassay. A significant rise in both gonadotropins was found after LH-RH; however, this increase did not exceed the baseline normal range. Rapid intravenous administration of LH-RH was repeated after five days of daily intramuscular injections of LH-RH. The rise in serum FSH and LH levels was similar to that of the first test. It is suggested that the minimal response to LHRH was probably not the result only of a chronic deprivation of releasing hormone but at least part of the disorder may involve the hypothalamus as well as the pituitary.

Original languageEnglish (US)
Pages (from-to)612-614
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - Mar 1973


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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