Effect of synthetic hypothalamic gonadotropin releasing hormone (FSH/LH RH) in anovulatory sterility

J. Zanartu, A. Dabancens, A. J. Kastin, A. V. Schally

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The gonadal response to treatment with synthetic hypothalamic follicle stimulating hormone/luteinizing releasing hormone (FSH/LH-RH) was studied in 2 groups of women with anovulation. The 7 women in group 2 had postpartum amenorrhea, anovulation, and abundant lactation. At laparotomies performed for elective tubal sterilization, the gonads were compared with those from an untreated control group (group 1). This group had 6 women in the fifth to the twelfth week postpartum who also had amenorrhea and lactation. Of the 7 women with postpartum anovulation treated with FSH/LH-RH, preovulatory mature follicles were observed at laparotomy in 4 and a fresh corpus luteum was found in 1. Group 3 consisted of 15 women with anovulation and sterility which presumably resulted from an idiopathic hypothalamic dysfunction. FSH/LH-RH was administered to induce pregnancy. Clinical signs of ovulation were induced in 13 of 28 treated cycles (10 patients). Pregnancy was established in 3 treated cycles and in 2 women in subsequent cycles. Small doses administered every 8 to 12 hr for 10 to 20 days seemed to be more effective than larger doses (0.5 mg) given less frequently. The results indicate that, in spite of considerable individual variation in the gonadal response to the stimulation, FSH/LH-RH treatment was effective in releasing endogenous gonadotropins as shown by follicular growth, maturation, and ovulation.

Original languageEnglish (US)
Pages (from-to)160-169
Number of pages10
JournalFertility and sterility
Issue number2
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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