Effect of surgical and chemotherapeutic treatment on alpha‐fetoprotein levels in patients with hepatocellular carcinoma

K. R. McIntire, C. L. Vogel, A. Primack, T. A. Waldmann, S. K. Kyalwazi

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Quantitative determinations of serum alpha fetoprotein (AFP) by radioimmunoassay in 193 patients with hepatocellular carcinoma have demonstrated a wide variation in serum levels that appear to be relatively constant for each patient by the time that diagnosis is made. If there is no therapeutic intervention the serum AFP usually follows a gradual increase as the tumor progresses. A few patients have a fall in serum AFP as a preterminal event. Various forms of chemotherapy cause only minor and transient decrease in serum AFP. Surgical resection of tumor produces an immediate fall that parallels the catabolic decay rate for AFP. All AFP positive patients treated with surgery had recurrence of their tumor with a rise in serum AFP preceding clinical discovery. The correlation of serum AFP and effective treatment is demonstration of the usefulness of this oncofetal protein marker as an indicator of neoplastic activity for hepatocellular carcinoma and tumors with embryonal cell components and possibly for some other entodermally derived neoplasms.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalCancer
Volume37
Issue number2
DOIs
StatePublished - Feb 1976
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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