Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol and alpha-tocopherol in humans

S. Mayne, B. Cartmel, F. Silva, B. Fallon, K. Briskin, M. Baum, G. Shor-Posner, W. Jarrard Goodwin

Research output: Contribution to journalArticle

Abstract

High-doses of beta-carotene (BC), a lipid-soluble nutrient, could potentially affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with BC (50 mg/day) on circulating levels of other carotenoids, retinol (A) and alpha-tocopherol (E). Data were available from 259 men and women participating in the Carotene Prevention Trial, a two center chemoprevention trial designed to determine whether or not supplemental BC could prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-month placebo run-in), with post-randomization samples obtained at 3, 12, 24, 36, 48, and 60 months. Bloods were analyzed by HPLC in 1 laboratory. Median nutrient levels (μg/mL) at baseline in the group randomized to receive BC were as follows (placebo group nearly identical): BC 0.12: A 0.48; E 12.2; alpha-carotene (AC) 0.024; lycopene (128; lutcin+zeaxanthin (L/Z) 0.14. Supplementation with BC produced a persistent 9 to 10-fold increase in median plasma BC levels (1.2 μg/mL at 3 months), and a persistent 2-fold increase in median plasma AC levels (0.051 μg/mL at 3 months). Concentrations of A, E, lycopene and L/Z were not affected by supplemental BC. Up to 5 years of daily supplementation with BC increases circulating levels of AC and BC, but does not alter levels of lycopene, L/Z, A, or E. CA 42101; CA 64567.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

beta Carotene
alpha-Tocopherol
Carotenoids
Vitamin A
alpha-tocopherol
vitamin A
beta-carotene
carotenoids
Plasmas
alpha-carotene
zeaxanthin
lycopene
Nutrients
Food
placebos
nutrients
Blood
Placebos
Lipids
chemoprevention

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol and alpha-tocopherol in humans. / Mayne, S.; Cartmel, B.; Silva, F.; Fallon, B.; Briskin, K.; Baum, M.; Shor-Posner, G.; Goodwin, W. Jarrard.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997.

Research output: Contribution to journalArticle

Mayne, S, Cartmel, B, Silva, F, Fallon, B, Briskin, K, Baum, M, Shor-Posner, G & Goodwin, WJ 1997, 'Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol and alpha-tocopherol in humans', FASEB Journal, vol. 11, no. 3.
Mayne, S. ; Cartmel, B. ; Silva, F. ; Fallon, B. ; Briskin, K. ; Baum, M. ; Shor-Posner, G. ; Goodwin, W. Jarrard. / Effect of supplemental beta-carotene on plasma concentrations of carotenoids, retinol and alpha-tocopherol in humans. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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