TY - JOUR
T1 - Effect of supplemental β-carotene on plasma concentrations of carotenoids, retinol, and α-tocopherol in humans
AU - Mayne, Susan T.
AU - Cartmel, Brenda
AU - Silva, Fabricio
AU - Kim, Chi S.
AU - Fallon, Barbara G.
AU - Briskin, Kenneth
AU - Zheng, Tongzhang
AU - Baum, Marianna
AU - Shor-Posner, Gail
AU - Goodwill, W. Jarrard
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1998/9
Y1 - 1998/9
N2 - High doses of β-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with β- carotene (50 mg/d) on circulating concentrations of other carotenoids, retinol, and α-tocopherol over time. Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental β-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with β-carotene produced a persistent 9- to 10-fold increase in median plasma β-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma α-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, α-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental β-carotene. Up to 5 y of daily supplementation with β- carotene increased circulating concentrations of α- and β-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or α- tocopherol.
AB - High doses of β-carotene, a lipid-soluble nutrient, may affect the plasma concentrations of other lipid-soluble nutrients. The purpose of this study was to assess the effects of long-term daily supplementation with β- carotene (50 mg/d) on circulating concentrations of other carotenoids, retinol, and α-tocopherol over time. Data were available from 259 men and women participating in the Carotene Prevention Trial, a 2-center chemoprevention trial designed to determine whether supplemental β-carotene can prevent second malignant tumors in patients cured of an early stage cancer of the oral cavity, pharynx, or larynx. Up to 2 blood samples were obtained before the intervention (before and after a 1-mo placebo run-in), with postrandomization samples obtained at 3, 12, 24, 36, 48, and 60 mo. Supplementation with β-carotene produced a persistent 9- to 10-fold increase in median plasma β-carotene concentrations (225 nmol/L at baseline to 2255 nmol/L at 3 mo) and a persistent 2-fold increase in median plasma α-carotene concentrations (45 nmol/L at baseline to 95 nmol/L at 3 mo). Concentrations of retinol, α-tocopherol, lycopene, and lutein/zeaxanthin were not affected by supplemental β-carotene. Up to 5 y of daily supplementation with β- carotene increased circulating concentrations of α- and β-carotene, but did not alter concentrations of lycopene, lutein/zeaxanthin, retinol, or α- tocopherol.
KW - α- tocopherol
KW - β- Carotene
KW - Adults
KW - Carotene Prevention Trial
KW - Carotenoids
KW - Humans
KW - Lutein/zeaxanthin
KW - Lycopene
KW - Retinol
KW - Supplements
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U2 - 10.1093/ajcn/68.3.642
DO - 10.1093/ajcn/68.3.642
M3 - Article
C2 - 9734742
AN - SCOPUS:0031667414
VL - 68
SP - 642
EP - 647
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -