TY - JOUR
T1 - Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model
AU - Jewett, Brian S.
AU - Cook, Raymond D.
AU - Johnson, Kenneth L.
AU - Logan, Thomas C.
AU - Shockley, William W.
N1 - Funding Information:
This study was performed in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals, the Principles of Laboratory Animal Care formulated by the National Society for Medical Research, and the NIH Guide for the Care of Use of Laboratory Animals (NIH publication NO. 80-23, revised 1978); the animal use protocol was approved by the Institutional Animal Care and Use Committee of the University of North Carolina.
PY - 2000
Y1 - 2000
N2 - OBJECTIVES: This study addresses the impact of stenting on early wound healing after laryngotracheal reconstruction (LTR) in a rabbit model with established subglottic stenosis. METHODS: Subglottic stenosis was created in 42 New Zealand white rabbits through a transoral, endoscopic technique. Three weeks later, endoscopy and axial CT were performed to document and grade the degree of stenosis. Subsequently, LTR was performed in all animals, with half of the animals receiving an intraluminal stent. Four rabbits from each group were euthanized on postoperative days 6, 9, 14, 21, and 28. Measurements of graft vascularization were obtained with a computerized image measurement program, and a comparison was made regarding the rate of vascularization. RESULTS: There was a statistically significant increase in the rate of vascularization in the stented group (mean 75% ± 5% vs 56% ± 3% at day 14; P < 0.05). However, clinical and radiographic comparisons of the stented and nonstented specimens revealed a trend toward increased mucosal edema and granulation tissue in the stented group at later time intervals (days 21 and 28). CONCLUSION: This analysis suggests that stenting does not inhibit graft vascularization in the early postoperative period after LTR; however, complications were seen in the stented group at longer time intervals.
AB - OBJECTIVES: This study addresses the impact of stenting on early wound healing after laryngotracheal reconstruction (LTR) in a rabbit model with established subglottic stenosis. METHODS: Subglottic stenosis was created in 42 New Zealand white rabbits through a transoral, endoscopic technique. Three weeks later, endoscopy and axial CT were performed to document and grade the degree of stenosis. Subsequently, LTR was performed in all animals, with half of the animals receiving an intraluminal stent. Four rabbits from each group were euthanized on postoperative days 6, 9, 14, 21, and 28. Measurements of graft vascularization were obtained with a computerized image measurement program, and a comparison was made regarding the rate of vascularization. RESULTS: There was a statistically significant increase in the rate of vascularization in the stented group (mean 75% ± 5% vs 56% ± 3% at day 14; P < 0.05). However, clinical and radiographic comparisons of the stented and nonstented specimens revealed a trend toward increased mucosal edema and granulation tissue in the stented group at later time intervals (days 21 and 28). CONCLUSION: This analysis suggests that stenting does not inhibit graft vascularization in the early postoperative period after LTR; however, complications were seen in the stented group at longer time intervals.
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U2 - 10.1067/mhn.2000.102112
DO - 10.1067/mhn.2000.102112
M3 - Article
C2 - 10740166
AN - SCOPUS:0034035017
VL - 122
SP - 488
EP - 494
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
SN - 0194-5998
IS - 4
ER -