Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model

Brian S. Jewett, Raymond D. Cook, Kenneth L. Johnson, Thomas C. Logan, William W. Shockley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: This study addresses the impact of stenting on early wound healing after laryngotracheal reconstruction (LTR) in a rabbit model with established subglottic stenosis. METHODS: Subglottic stenosis was created in 42 New Zealand white rabbits through a transoral, endoscopic technique. Three weeks later, endoscopy and axial CT were performed to document and grade the degree of stenosis. Subsequently, LTR was performed in all animals, with half of the animals receiving an intraluminal stent. Four rabbits from each group were euthanized on postoperative days 6, 9, 14, 21, and 28. Measurements of graft vascularization were obtained with a computerized image measurement program, and a comparison was made regarding the rate of vascularization. RESULTS: There was a statistically significant increase in the rate of vascularization in the stented group (mean 75% ± 5% vs 56% ± 3% at day 14; P < 0.05). However, clinical and radiographic comparisons of the stented and nonstented specimens revealed a trend toward increased mucosal edema and granulation tissue in the stented group at later time intervals (days 21 and 28). CONCLUSION: This analysis suggests that stenting does not inhibit graft vascularization in the early postoperative period after LTR; however, complications were seen in the stented group at longer time intervals.

Original languageEnglish
Pages (from-to)488-494
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume122
Issue number4
StatePublished - Apr 28 2000
Externally publishedYes

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Pathologic Constriction
Rabbits
Transplants
Granulation Tissue
Postoperative Period
Wound Healing
Endoscopy
Stents
Edema
Mucous Membrane

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Jewett, B. S., Cook, R. D., Johnson, K. L., Logan, T. C., & Shockley, W. W. (2000). Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model. Otolaryngology - Head and Neck Surgery, 122(4), 488-494.

Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model. / Jewett, Brian S.; Cook, Raymond D.; Johnson, Kenneth L.; Logan, Thomas C.; Shockley, William W.

In: Otolaryngology - Head and Neck Surgery, Vol. 122, No. 4, 28.04.2000, p. 488-494.

Research output: Contribution to journalArticle

Jewett, BS, Cook, RD, Johnson, KL, Logan, TC & Shockley, WW 2000, 'Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model', Otolaryngology - Head and Neck Surgery, vol. 122, no. 4, pp. 488-494.
Jewett BS, Cook RD, Johnson KL, Logan TC, Shockley WW. Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model. Otolaryngology - Head and Neck Surgery. 2000 Apr 28;122(4):488-494.
Jewett, Brian S. ; Cook, Raymond D. ; Johnson, Kenneth L. ; Logan, Thomas C. ; Shockley, William W. / Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model. In: Otolaryngology - Head and Neck Surgery. 2000 ; Vol. 122, No. 4. pp. 488-494.
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