Effect of stenosis shape on thrombus formation in an in vitro blood flow model

Steven A. Jones, Pascal Goldschmidt-Clermont, Dmitriy Grigoryev, Thomas Aversano

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Experiments were performed on an in vitro stenosis model to determine whether stenosis geometry has an effect on the localization of patelet thrombus. The model was designed so that the wall shear stress differed substantially as a function of the flow direction For flow in the forward direction, thrombus was found in a region where the wall shear stress was between 150 and 300 dynes/cm 2, but not in regions where the shear stress was much lower or much higher than this. For flow in the reverse direction, no thrombus was found No thrombus was found at or distal to the region of turbulent flow, but thrombus was eliminated when the turbulent portion of the model was eliminated. The results indicate that both hemodynamics and thrombus formation are sensitive to stenosis shape and that turbulence may contribute to shear induced thrombus formation.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Pages279-280
Number of pages2
Volume35
StatePublished - 1997
Externally publishedYes

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Shear stress
Blood
Hemodynamics
Turbulent flow
Turbulence
Geometry
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jones, S. A., Goldschmidt-Clermont, P., Grigoryev, D., & Aversano, T. (1997). Effect of stenosis shape on thrombus formation in an in vitro blood flow model. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED (Vol. 35, pp. 279-280)

Effect of stenosis shape on thrombus formation in an in vitro blood flow model. / Jones, Steven A.; Goldschmidt-Clermont, Pascal; Grigoryev, Dmitriy; Aversano, Thomas.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 35 1997. p. 279-280.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jones, SA, Goldschmidt-Clermont, P, Grigoryev, D & Aversano, T 1997, Effect of stenosis shape on thrombus formation in an in vitro blood flow model. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 35, pp. 279-280.
Jones SA, Goldschmidt-Clermont P, Grigoryev D, Aversano T. Effect of stenosis shape on thrombus formation in an in vitro blood flow model. In American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 35. 1997. p. 279-280
Jones, Steven A. ; Goldschmidt-Clermont, Pascal ; Grigoryev, Dmitriy ; Aversano, Thomas. / Effect of stenosis shape on thrombus formation in an in vitro blood flow model. American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 35 1997. pp. 279-280
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