Effect of static compressive strain, anisotropy, and tissue region on the diffusion of glucose in meniscus fibrocartilage

Kelsey L. Kleinhans, Lukas M. Jaworski, Michaela Schneiderbauer, Alicia Renee Jackson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a significant socio-economic concern, affecting millions of individuals each year. Degeneration of the meniscus of the knee is often associated with OA, yet the relationship between the two is not well understood. As a nearly avascular tissue, the meniscus must rely on diffusive transport for nutritional supply to cells. Therefore, quantifying structure-function relations for transport properties in meniscus fibrocartilage is an important task. The purpose of the present study was to determine how mechanical loading, tissue anisotropy, and tissue region affect glucose diffusion in meniscus fibrocartilage. A one-dimensional (1D) diffusion experiment was used to measure the diffusion coefficient of glucose in porcine meniscus tissues. Results show that glucose diffusion is strain-dependent, decreasing significantly with increased levels of compression. It was also determined that glucose diffusion in meniscus tissues is anisotropic, with the diffusion coefficient in the circumferential direction being significantly higher than that in the axial direction. Finally, the effect of tissue region was not statistically significant, comparing axial diffusion in the central and horn regions of the tissue. This study is important for better understanding the transport and nutrition-related mechanisms of meniscal degeneration and related OA in the knee.

Original languageEnglish (US)
Article number101004
JournalJournal of Biomechanical Engineering
Volume137
Issue number10
DOIs
StatePublished - Oct 1 2015

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Fibrocartilage
Anisotropy
Glucose
Tissue
Osteoarthritis
Knee Osteoarthritis
Horns
Nutrition
Meniscus
Transport properties
Knee
Swine
Economics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Effect of static compressive strain, anisotropy, and tissue region on the diffusion of glucose in meniscus fibrocartilage. / Kleinhans, Kelsey L.; Jaworski, Lukas M.; Schneiderbauer, Michaela; Jackson, Alicia Renee.

In: Journal of Biomechanical Engineering, Vol. 137, No. 10, 101004, 01.10.2015.

Research output: Contribution to journalArticle

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