Effect of somatostatin on TSH levels in non-toxic sporadic goiter

J. Varea; M. Paredes; G. Garces; C. Ochoa; C. Avila; M. J. Coloma; R. Briones; A. M. Comaru-Schally; A. V. Schally

doi:10.1055/s-2007-1004989

Effect of somatostatin on TSH levels in non-toxic sporadic goiter

J. Varea, M. Paredes, G. Garces, C. Ochoa, C. Avila, M. J. Coloma, R. Briones, A. M. Comaru-Schally, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

Somatostatin (SS-14; growth hormone-release inhibiting hormone) was infused into eight patients with non-toxic sporadic goiter and into eleven normal control subjects. Each patient was given 150 μg of somatostatin as an intravenous bolus and 350 μg by infusion over a period of 60 minutes. Somatostatin did not lower the basal TSH levels as compared to the pre-infusion levels in this type of goiter, but produced a decrease in the TSH response to TRH during and after the infusion.

Original language	English (US)
Pages (from-to)	627-631
Number of pages	5
Journal	Hormone and Metabolic Research
Volume	22
Issue number	12
DOIs	https://doi.org/10.1055/s-2007-1004989
State	Published - Jan 1 1990
Externally published	Yes

Keywords

goiter
somatostatin
TRH
TSH

ASJC Scopus subject areas

Biochemistry
Endocrinology

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abstract = "Somatostatin (SS-14; growth hormone-release inhibiting hormone) was infused into eight patients with non-toxic sporadic goiter and into eleven normal control subjects. Each patient was given 150 μg of somatostatin as an intravenous bolus and 350 μg by infusion over a period of 60 minutes. Somatostatin did not lower the basal TSH levels as compared to the pre-infusion levels in this type of goiter, but produced a decrease in the TSH response to TRH during and after the infusion.",

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AU - Varea, J.

AU - Paredes, M.

AU - Garces, G.

AU - Ochoa, C.

AU - Avila, C.

AU - Coloma, M. J.

AU - Briones, R.

AU - Comaru-Schally, A. M.

AU - Schally, A. V.

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Y1 - 1990/1/1

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KW - somatostatin

KW - TRH

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