The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochemical and biophysical research communications|
|State||Published - May 31 1985|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology