Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

Marek Pawlikowski; Henryk Stepien; Jolanta Kunert-Radek; Andrew V. Schally

doi:10.1016/0006-291X(85)91401-9

Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

Marek Pawlikowski, Henryk Stepien, Jolanta Kunert-Radek, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of ³H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10^-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.

Original language	English (US)
Pages (from-to)	52-55
Number of pages	4
Journal	Biochemical and biophysical research communications
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(85)91401-9
State	Published - May 31 1985
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(85)91401-9

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title = "Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro",

abstract = "The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.",

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AU - Pawlikowski, Marek

AU - Stepien, Henryk

AU - Kunert-Radek, Jolanta

AU - Schally, Andrew V.

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AB - The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.

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Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

Abstract

ASJC Scopus subject areas

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