Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

Marek Pawlikowski, Henryk Stepien, Jolanta Kunert-Radek, Andrew V. Schally

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.

Original languageEnglish (US)
Pages (from-to)52-55
Number of pages4
JournalBiochemical and biophysical research communications
Volume129
Issue number1
DOIs
StatePublished - May 31 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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