Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

Marek Pawlikowski, Henryk Stepien, Jolanta Kunert-Radek, Andrew V Schally

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The effect of somatostatin on the spontaneous proliferation of mouse spleen lymphocytes was investigated invitro. The rate of 3H-thymidine incorporation was used as an index of lymphocyte proliferation. Somatostatin in a concentration of 10-7M enhanced the lymphocyte proliferation and abolished the antiproliferative effect of rat hypothalamic extract. Lower concentrations of somatostatin slightly decreased the lymphocyte DNA synthesis.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume129
Issue number1
DOIs
StatePublished - May 31 1985
Externally publishedYes

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Lymphocytes
Somatostatin
Spleen
Thymidine
Rats
In Vitro Techniques
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro. / Pawlikowski, Marek; Stepien, Henryk; Kunert-Radek, Jolanta; Schally, Andrew V.

In: Biochemical and Biophysical Research Communications, Vol. 129, No. 1, 31.05.1985, p. 52-55.

Research output: Contribution to journalArticle

Pawlikowski, Marek ; Stepien, Henryk ; Kunert-Radek, Jolanta ; Schally, Andrew V. / Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro. In: Biochemical and Biophysical Research Communications. 1985 ; Vol. 129, No. 1. pp. 52-55.
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