Effect of somatostatin on gastrointestinal secretions and peptic ulcer production in cats

Stanislaw J. Konturek, Tadeusz Radecki, Anna Pucher, David H. Coy, Andrew V. Schally

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In conscious cats with chronic gastric and pancreatic fistulas, the effect of somatostatin (GH-RIH) on gastric and pancreatic secretion and peptic ulcer formation was examined. GH-RIH infused intravenously in graded doses (range: 0.62 to 5.0 μg/kg-hr) inhibited dose-dependently gastric acid response to pentagastrin but failed to affect acid response to histamine. GH-RIH caused a marked inhibition of pepsin secretion induced by both pentagastrin and histamine and decreased pancreatic bicarbonate but not protein response to exogenous secretin or intraduodenal acid. It effectively prevented the formation of duodenal ulcers produced by prolonged administration of both pentagastrin or histamine.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume12
Issue number3
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Keywords

  • Cat
  • Gastric secretion
  • Peptic ulcer
  • Somatostatin
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology

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