Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)