Effect of somatostatin analogs on gastric and pancreatic secretion

S. J. Konturek, J. Tasler, R. Krol, A. Dembinski, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume155
Issue number4
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Somatostatin
Growth Hormone
Stomach
Hormones
Gastric Fistula
Pancreatic Fistula
Pentagastrin
Secretin
Gastric Acid
Bicarbonates
Dogs
Peptides
Acids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of somatostatin analogs on gastric and pancreatic secretion. / Konturek, S. J.; Tasler, J.; Krol, R.; Dembinski, A.; Coy, D. H.; Schally, Andrew V.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 155, No. 4, 01.12.1977, p. 519-522.

Research output: Contribution to journalArticle

Konturek, SJ, Tasler, J, Krol, R, Dembinski, A, Coy, DH & Schally, AV 1977, 'Effect of somatostatin analogs on gastric and pancreatic secretion', Proceedings of the Society for Experimental Biology and Medicine, vol. 155, no. 4, pp. 519-522.
Konturek, S. J. ; Tasler, J. ; Krol, R. ; Dembinski, A. ; Coy, D. H. ; Schally, Andrew V. / Effect of somatostatin analogs on gastric and pancreatic secretion. In: Proceedings of the Society for Experimental Biology and Medicine. 1977 ; Vol. 155, No. 4. pp. 519-522.
@article{181c5ba826f043b4b698c8c5afafbf48,
title = "Effect of somatostatin analogs on gastric and pancreatic secretion",
abstract = "Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.",
author = "Konturek, {S. J.} and J. Tasler and R. Krol and A. Dembinski and Coy, {D. H.} and Schally, {Andrew V}",
year = "1977",
month = "12",
day = "1",
language = "English",
volume = "155",
pages = "519--522",
journal = "Experimental Biology and Medicine",
issn = "0037-9727",
publisher = "Society for Experimental Biology and Medicine",
number = "4",

}

TY - JOUR

T1 - Effect of somatostatin analogs on gastric and pancreatic secretion

AU - Konturek, S. J.

AU - Tasler, J.

AU - Krol, R.

AU - Dembinski, A.

AU - Coy, D. H.

AU - Schally, Andrew V

PY - 1977/12/1

Y1 - 1977/12/1

N2 - Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.

AB - Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.

UR - http://www.scopus.com/inward/record.url?scp=0017705316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017705316&partnerID=8YFLogxK

M3 - Article

C2 - 331342

AN - SCOPUS:0017705316

VL - 155

SP - 519

EP - 522

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 0037-9727

IS - 4

ER -