Effect of Somatostatin Analogs on Gastric and Pancreatic Secretion

Stanislaw J. Konturek, Janina Tasler, Ryszard Krol, Artur Dembinski, David H. Coy, Andrew V. Schally

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Growth hormone release-inhibiting hormone (GH-RIH) and its two analogs, D-Trp 8-somatostatin and D-Cys 14-somatostatin were tested for their effects on gastric and pancreatic secretion in chronic gastric and pancreatic fistula dogs. All 3 peptides caused similar competitive inhibition of pentagastrin-induced gastric acid and secretin-induced pancreatic bicarbonate secretions. This study indicates that GH-RIH analogs, which were shown to have a dissociated action on pituitary and endocrine pancreatic secretion, are essentially as equipotent as GH-RIH itself on gastric and pancreatic secretions.

Original languageEnglish (US)
Pages (from-to)519-522
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume155
Issue number4
DOIs
StatePublished - Sep 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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