Effect of somatostatin analogs on gastric acid secretion in dogs and rats

ANDREW V. SCHALLY, JOHN COLALUCA, DALE PAULSON, WELDON H. CARTER, HAL R. NEITZSCHMAN, HADEN LAFAYE, R. ‐Z CAI

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effects of several superactive analogs of somatostatin on gastric acid response to various exogenous and endogenous stimulants were investigated in conscious dogs and rats with gastric fistulae (GF). The inhibition was compared to that induced by somatostatin‐14 (S‐S‐14) at two dose levels. Several octapeptide analogs of somatostatin including (RC‐160) and (RC‐121), which were superactive in tests on suppression of GH levels, were 4‐5 times more potent than S‐S‐14 in inhibiting desglugastrin‐stimulated gastric acid secretion in GF dogs. The analog RC‐160 also reduced the rise in serum gastrin levels and gastric acid secretion induced by sham feeding (SF) in dogs with gastric and esophageal fistulae (EF), but did not decrease food consumption. Gastric acid secretion induced by histamine (80μg/kg/h) in dogs was not affected by 1‐5μg/kg/h of analog RC‐121 or by 5μg/kg/h of S‐S‐14. Analogs RC‐160, RC‐121, and RC‐98‐I and others also powerfully inhibited desglugastrin‐induced gastric acid secretion in GF rats. Hexapeptide cyclo(‐Pro‐Phe‐D‐Trp‐Lys‐Thr‐Phe) was only about half as potent as S‐S‐14 in dogs but its activity was higher in rats. The results indicate that octapeptide analogs which are superactive in GH‐inhibition tests are also more potent than S‐S‐14 in suppressing gastric acid secretion. These findings may be of clinical value.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalInternational journal of peptide and protein research
Volume36
Issue number3
DOIs
StatePublished - Sep 1990

Keywords

  • inhibition of gastrin and gastric acid
  • octapeptide analogs of somatostatin

ASJC Scopus subject areas

  • Biochemistry

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