Effect of recombinant il‐3 on lymphocyte populations in irradiated mice

Gino Doria, Giorgio Leter, Camillo Mancini, Daniela Frasca

Research output: Contribution to journalArticle

Abstract

Administration of murine recombinant interleukin 3 (IL‐3) to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to Con A, as well as a decrease in CD4CD8 cells concomitant with an increase in single positive cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide (LPS) were recovered by IL‐3 treatment. These findings show that IL‐3 induces differentiation and growth of thymocytes and recovery of T and B cell functions in sublethally irradiated mice.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalSTEM CELLS
Volume11
Issue number2 S
DOIs
StatePublished - Jul 1993
Externally publishedYes

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Keywords

  • B cells
  • Interleukin 3
  • T cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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