Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs

Om P. Sharma, Rajinder K. Dawra, Harinder P.S. Makkar

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A partially purified preparation of toxin isolated from lantana (Lantana camara L., red variety) leaves, called fraction C, was obtained in two crystalline forms: form I, white, fluffy, rod-shaped and form II, irregular, polyhedral, shining crystals. The two forms differed in melting point behaviour and icterogenic action when administered orally to guinea pigs. Only form II was icterogenic to guinea pigs and was associated with decreased feed intake and faecal output, hepatomegaly, increase in plasma bilirubin level and acid phosphatase activity.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalToxicology Letters
Volume42
Issue number1
DOIs
StatePublished - Jul 1988
Externally publishedYes

Keywords

  • (Guinea pig)
  • Crystal polymorphism
  • Lantana
  • Lantana camara'
  • Toxin

ASJC Scopus subject areas

  • Toxicology

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