Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi

Claudia O. Rodrigues; Patrícia M.L. Dutra; Thais Souto-Padrón; Renato S.B. Cordeiro; Angela H.C.S. Lopes

doi:10.1006/bbrc.1996.0965

Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi

Claudia O. Rodrigues, Patrícia M.L. Dutra, Thais Souto-Padrón, Renato S.B. Cordeiro, Angela H.C.S. Lopes

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

The effects of platelet-activating factor (PAF), at 10^-6 M and 10^-9 M, on cell growth and cell differentiation of Trypanosoma cruzi were investigated. Cell differentiation was evaluated by both light and electron microscopy. At the concentrations used, PAF slightly interfered with the protozoan growth. However, parasites growth in the presence of PAF were significantly more differentiated than those grown in the absence of PAF, beginning on the fourth day of culture. A specific PAF receptor antagonist (WEB 2086) totally abrogated PAF effect on cell differentiation. These findings indicate that PAF triggers the process of cell differentiation in T. cruzi and suggest that these parasites have receptors for PAF.

Original language	English (US)
Pages (from-to)	735-740
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	223
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.1996.0965
State	Published - Jun 25 1996
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.1996.0965

Fingerprint Dive into the research topics of 'Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi'. Together they form a unique fingerprint.

Cite this

Rodrigues, C. O., Dutra, P. M. L., Souto-Padrón, T., Cordeiro, R. S. B., & Lopes, A. H. C. S. (1996). Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. Biochemical and biophysical research communications, 223(3), 735-740. https://doi.org/10.1006/bbrc.1996.0965

@article{e590d1ee966e4b7db9fb3c37decb0240,

title = "Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi",

abstract = "The effects of platelet-activating factor (PAF), at 10-6 M and 10-9 M, on cell growth and cell differentiation of Trypanosoma cruzi were investigated. Cell differentiation was evaluated by both light and electron microscopy. At the concentrations used, PAF slightly interfered with the protozoan growth. However, parasites growth in the presence of PAF were significantly more differentiated than those grown in the absence of PAF, beginning on the fourth day of culture. A specific PAF receptor antagonist (WEB 2086) totally abrogated PAF effect on cell differentiation. These findings indicate that PAF triggers the process of cell differentiation in T. cruzi and suggest that these parasites have receptors for PAF.",

author = "Rodrigues, {Claudia O.} and Dutra, {Patr{\'i}cia M.L.} and Thais Souto-Padr{\'o}n and Cordeiro, {Renato S.B.} and Lopes, {Angela H.C.S.}",

year = "1996",

month = jun,

day = "25",

doi = "10.1006/bbrc.1996.0965",

language = "English (US)",

volume = "223",

pages = "735--740",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi

AU - Rodrigues, Claudia O.

AU - Dutra, Patrícia M.L.

AU - Souto-Padrón, Thais

AU - Cordeiro, Renato S.B.

AU - Lopes, Angela H.C.S.

PY - 1996/6/25

Y1 - 1996/6/25

N2 - The effects of platelet-activating factor (PAF), at 10-6 M and 10-9 M, on cell growth and cell differentiation of Trypanosoma cruzi were investigated. Cell differentiation was evaluated by both light and electron microscopy. At the concentrations used, PAF slightly interfered with the protozoan growth. However, parasites growth in the presence of PAF were significantly more differentiated than those grown in the absence of PAF, beginning on the fourth day of culture. A specific PAF receptor antagonist (WEB 2086) totally abrogated PAF effect on cell differentiation. These findings indicate that PAF triggers the process of cell differentiation in T. cruzi and suggest that these parasites have receptors for PAF.

AB - The effects of platelet-activating factor (PAF), at 10-6 M and 10-9 M, on cell growth and cell differentiation of Trypanosoma cruzi were investigated. Cell differentiation was evaluated by both light and electron microscopy. At the concentrations used, PAF slightly interfered with the protozoan growth. However, parasites growth in the presence of PAF were significantly more differentiated than those grown in the absence of PAF, beginning on the fourth day of culture. A specific PAF receptor antagonist (WEB 2086) totally abrogated PAF effect on cell differentiation. These findings indicate that PAF triggers the process of cell differentiation in T. cruzi and suggest that these parasites have receptors for PAF.

UR - http://www.scopus.com/inward/record.url?scp=0030601084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030601084&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1996.0965

DO - 10.1006/bbrc.1996.0965

M3 - Article

C2 - 8687466

AN - SCOPUS:0030601084

VL - 223

SP - 735

EP - 740

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -