Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi

Claudia D Rodrigues, Patrícia M L Dutra, Thais Souto-Padrón, Renato S B Cordeiro, Angela H C S Lopes

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of platelet-activating factor (PAF), at 10-6 M and 10-9 M, on cell growth and cell differentiation of Trypanosoma cruzi were investigated. Cell differentiation was evaluated by both light and electron microscopy. At the concentrations used, PAF slightly interfered with the protozoan growth. However, parasites growth in the presence of PAF were significantly more differentiated than those grown in the absence of PAF, beginning on the fourth day of culture. A specific PAF receptor antagonist (WEB 2086) totally abrogated PAF effect on cell differentiation. These findings indicate that PAF triggers the process of cell differentiation in T. cruzi and suggest that these parasites have receptors for PAF.

Original languageEnglish
Pages (from-to)735-740
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume223
Issue number3
DOIs
StatePublished - Jun 25 1996
Externally publishedYes

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Trypanosoma cruzi
Platelet Activating Factor
Cell Differentiation
WEB 2086
Parasites
Growth
Cell growth
Electron microscopy
Optical microscopy
Electron Microscopy
Light

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. / Rodrigues, Claudia D; Dutra, Patrícia M L; Souto-Padrón, Thais; Cordeiro, Renato S B; Lopes, Angela H C S.

In: Biochemical and Biophysical Research Communications, Vol. 223, No. 3, 25.06.1996, p. 735-740.

Research output: Contribution to journalArticle

Rodrigues, Claudia D ; Dutra, Patrícia M L ; Souto-Padrón, Thais ; Cordeiro, Renato S B ; Lopes, Angela H C S. / Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 223, No. 3. pp. 735-740.
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