Effect of Pentobarbital and Ether Stress on Serum Prolactin Levels in Rats

Ichiji Wakabayashi, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Ether inhalation for 1 min significantly increased serum prolactin levels in both male and female rats. Serum prolactin levels reached a peak within 2.5 min after exposure to ether vapor and returned to resting levels by 15 min. Handling of female rats for 4 days lowered serum prolactin levels but the same procedure raised prolactin levels in male rats. Injection of 3.5 mg of pentobarbital/100 g of body wt ip increased serum prolactin levels in female rats over a period of 60 min as compared with saline-injected controls; the peak was reached around 30 min after injection. In male rats, however, the same dose of pentobarbital induced only a slight increase in serum prolactin. It required injection of 5 mg pentobarbital/100 g of body wt for male rats to cause a significant increase of serum prolactin. The pattern of serum prolactin changes after 5 mg of pentobarbital in male rats was similar to that obtained in female rats with a smaller dose. These results indicate that serum prolactin levels are readily influenced by handling, ether inhalation and pentobarbital, but the extent of these changes varies between the sexes.

Original languageEnglish (US)
Pages (from-to)1189-1193
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Sep 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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