Abstract
Ether inhalation for 1 min significantly increased serum prolactin levels in both male and female rats. Serum prolactin levels reached a peak within 2.5 min after exposure to ether vapor and returned to resting levels by 15 min. Handling of female rats for 4 days lowered serum prolactin levels but the same procedure raised prolactin levels in male rats. Injection of 3.5 mg of pentobarbital/100 g of body wt ip increased serum prolactin levels in female rats over a period of 60 min as compared with saline-injected controls; the peak was reached around 30 min after injection. In male rats, however, the same dose of pentobarbital induced only a slight increase in serum prolactin. It required injection of 5 mg pentobarbital/100 g of body wt for male rats to cause a significant increase of serum prolactin. The pattern of serum prolactin changes after 5 mg of pentobarbital in male rats was similar to that obtained in female rats with a smaller dose. These results indicate that serum prolactin levels are readily influenced by handling, ether inhalation and pentobarbital, but the extent of these changes varies between the sexes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1189-1193 |
| Number of pages | 5 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 137 |
| Issue number | 4 |
| DOIs | |
| State | Published - Sep 1971 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)