Ether inhalation for 1 min significantly increased serum prolactin levels in both male and female rats. Serum prolactin levels reached a peak within 2.5 min after exposure to ether vapor and returned to resting levels by 15 min. Handling of female rats for 4 days lowered serum prolactin levels but the same procedure raised prolactin levels in male rats. Injection of 3.5 mg of pentobarbital/100 g of body wt ip increased serum prolactin levels in female rats over a period of 60 min as compared with saline-injected controls; the peak was reached around 30 min after injection. In male rats, however, the same dose of pentobarbital induced only a slight increase in serum prolactin. It required injection of 5 mg pentobarbital/100 g of body wt for male rats to cause a significant increase of serum prolactin. The pattern of serum prolactin changes after 5 mg of pentobarbital in male rats was similar to that obtained in female rats with a smaller dose. These results indicate that serum prolactin levels are readily influenced by handling, ether inhalation and pentobarbital, but the extent of these changes varies between the sexes.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Sep 1971|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)