Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants

Brenda B. Poindexter, Richard A. Ehrenkranz, Barbara J. Stoll, Matthew A. Koch, Linda L. Wright, William Oh, Lu Ann Papile, Charles R Bauer, Waldemar A. Carlo, Edward F. Donovan, Avroy A. Fanaroff, Sheldon B. Korones, Abbot R. Laptook, Seetha Shankaran, David K. Stevenson, Jon E. Tyson, James A. Lemons

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: Glutamine is one of the most abundant amino acids in both plasma and human milk and may be conditionally essential in premature infants. However, glutamine is not provided by standard intravenous amino acid solutions. Objective: We assessed the effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants receiving parenteral nutrition (PN). Design: A total of 141 infants with birth weights of 401-1000 g were randomly assigned to receive a standard intravenous amino acid solution that did not contain glutamine or an isonitrogenous amino acid solution with 20% of the total amino acids as glutamine. Blood samples were obtained just before initiation of study PN and again after the infants had received study PN (mean intake: 2.3 ± 1.0 g amino acids · kg-1 · d-1 for ≈10 d. Results: Infants randomly assigned to receive glutamine had mean plasma glutamine concentrations that increased significantly and were ≈30% higher than those in the control group in response to PN (425 ± 182 and 332 ± 148 μmol/L for the glutamine and control groups, respectively). There was no significant difference between the 2 groups in the relative change in plasma glutamate concentration between the baseline and PN samples. In both groups, there were significant decreases in plasma phenylalanine and tyrosine between the baseline and PN samples; the decrease in tyrosine was greater in the group that received glutamine. Conclusions: In extremely low-birth-weight infants, parenteral glutamine supplementation can increase plasma glutamine concentrations without apparent biochemical risk. Currently available amino acid solutions are likely to be suboptimal in their supply of phenylalanine, tyrosine, or both for these infants.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume77
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Extremely Low Birth Weight Infant
low birth weight
Glutamine
glutamine
Amino Acids
Parenteral Nutrition
amino acids
parenteral feeding
Tyrosine
tyrosine
Phenylalanine
phenylalanine
infant nutrition
Control Groups
Human Milk
breast milk
Birth Weight
Premature Infants
sampling
birth weight

Keywords

  • Extremely low-birth-weight
  • Glutamine
  • Low-birth-weight infants
  • Neonatal care
  • Neonatology
  • Parenteral nutrition
  • Phenylalanine
  • Premature infants
  • Tyrosine

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Poindexter, B. B., Ehrenkranz, R. A., Stoll, B. J., Koch, M. A., Wright, L. L., Oh, W., ... Lemons, J. A. (2003). Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants. American Journal of Clinical Nutrition, 77(3), 737-743.

Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants. / Poindexter, Brenda B.; Ehrenkranz, Richard A.; Stoll, Barbara J.; Koch, Matthew A.; Wright, Linda L.; Oh, William; Papile, Lu Ann; Bauer, Charles R; Carlo, Waldemar A.; Donovan, Edward F.; Fanaroff, Avroy A.; Korones, Sheldon B.; Laptook, Abbot R.; Shankaran, Seetha; Stevenson, David K.; Tyson, Jon E.; Lemons, James A.

In: American Journal of Clinical Nutrition, Vol. 77, No. 3, 01.03.2003, p. 737-743.

Research output: Contribution to journalArticle

Poindexter, BB, Ehrenkranz, RA, Stoll, BJ, Koch, MA, Wright, LL, Oh, W, Papile, LA, Bauer, CR, Carlo, WA, Donovan, EF, Fanaroff, AA, Korones, SB, Laptook, AR, Shankaran, S, Stevenson, DK, Tyson, JE & Lemons, JA 2003, 'Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants', American Journal of Clinical Nutrition, vol. 77, no. 3, pp. 737-743.
Poindexter, Brenda B. ; Ehrenkranz, Richard A. ; Stoll, Barbara J. ; Koch, Matthew A. ; Wright, Linda L. ; Oh, William ; Papile, Lu Ann ; Bauer, Charles R ; Carlo, Waldemar A. ; Donovan, Edward F. ; Fanaroff, Avroy A. ; Korones, Sheldon B. ; Laptook, Abbot R. ; Shankaran, Seetha ; Stevenson, David K. ; Tyson, Jon E. ; Lemons, James A. / Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants. In: American Journal of Clinical Nutrition. 2003 ; Vol. 77, No. 3. pp. 737-743.
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AU - Ehrenkranz, Richard A.

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AU - Koch, Matthew A.

AU - Wright, Linda L.

AU - Oh, William

AU - Papile, Lu Ann

AU - Bauer, Charles R

AU - Carlo, Waldemar A.

AU - Donovan, Edward F.

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AU - Korones, Sheldon B.

AU - Laptook, Abbot R.

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AU - Lemons, James A.

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N2 - Background: Glutamine is one of the most abundant amino acids in both plasma and human milk and may be conditionally essential in premature infants. However, glutamine is not provided by standard intravenous amino acid solutions. Objective: We assessed the effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants receiving parenteral nutrition (PN). Design: A total of 141 infants with birth weights of 401-1000 g were randomly assigned to receive a standard intravenous amino acid solution that did not contain glutamine or an isonitrogenous amino acid solution with 20% of the total amino acids as glutamine. Blood samples were obtained just before initiation of study PN and again after the infants had received study PN (mean intake: 2.3 ± 1.0 g amino acids · kg-1 · d-1 for ≈10 d. Results: Infants randomly assigned to receive glutamine had mean plasma glutamine concentrations that increased significantly and were ≈30% higher than those in the control group in response to PN (425 ± 182 and 332 ± 148 μmol/L for the glutamine and control groups, respectively). There was no significant difference between the 2 groups in the relative change in plasma glutamate concentration between the baseline and PN samples. In both groups, there were significant decreases in plasma phenylalanine and tyrosine between the baseline and PN samples; the decrease in tyrosine was greater in the group that received glutamine. Conclusions: In extremely low-birth-weight infants, parenteral glutamine supplementation can increase plasma glutamine concentrations without apparent biochemical risk. Currently available amino acid solutions are likely to be suboptimal in their supply of phenylalanine, tyrosine, or both for these infants.

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