TY - JOUR
T1 - Effect of nitroso-redox imbalance on male reproduction
AU - Kuchakulla, Manish
AU - Masterson, Thomas
AU - Arora, Himanshu
AU - Kulandavelu, Shathiyah
AU - Ramasamy, Ranjith
N1 - Funding Information:
This work was supported by the American Urological Association Research Scholar Award and Stanley Glaser Award to R Ramasamy.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are byproducts of normal metabolic processes. They are necessary for normal cellular function and are kept in balance by antioxidant mechanisms. Alterations in levels of ROS and RNS can lead to nitroso-redox imbalance that in turn can negatively affect male reproduction. Strategies to decrease ROS/RNS involve evasion of exposures (smoking, meat intake, pollution, calorie-dense diet), managing lifestyle, and increasing the consumption of antioxidants (vitamin C, vitamin E, alpha-lipoic acid, taurine, quercetin). Targeted therapies focusing on nitroso-redox imbalance can be critical for treatment of male reproductive dysfunction. This review outlines endogenous and exogenous sources of ROS/RNS, adverse effect on male reproduction, and strategies to control nitroso-redox imbalance.
AB - Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are byproducts of normal metabolic processes. They are necessary for normal cellular function and are kept in balance by antioxidant mechanisms. Alterations in levels of ROS and RNS can lead to nitroso-redox imbalance that in turn can negatively affect male reproduction. Strategies to decrease ROS/RNS involve evasion of exposures (smoking, meat intake, pollution, calorie-dense diet), managing lifestyle, and increasing the consumption of antioxidants (vitamin C, vitamin E, alpha-lipoic acid, taurine, quercetin). Targeted therapies focusing on nitroso-redox imbalance can be critical for treatment of male reproductive dysfunction. This review outlines endogenous and exogenous sources of ROS/RNS, adverse effect on male reproduction, and strategies to control nitroso-redox imbalance.
KW - Male reproduction
KW - Nitric oxide synthase (NOS)
KW - Nitroso-redox imbalance
KW - Reactive nitrogen species (RNS)
KW - Reactive oxygen species (ROS)
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U2 - 10.21037/tau.2018.08.14
DO - 10.21037/tau.2018.08.14
M3 - Review article
AN - SCOPUS:85057105065
VL - 7
SP - 968
EP - 977
JO - Translational Andrology and Urology
JF - Translational Andrology and Urology
SN - 2223-4683
IS - 6
ER -