Effect of nitroso-redox imbalance on male reproduction

Manish Kuchakulla, Thomas Masterson, Himanshu Arora, Shathiyah Kulandavelu, Ranjith Ramasamy

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are byproducts of normal metabolic processes. They are necessary for normal cellular function and are kept in balance by antioxidant mechanisms. Alterations in levels of ROS and RNS can lead to nitroso-redox imbalance that in turn can negatively affect male reproduction. Strategies to decrease ROS/RNS involve evasion of exposures (smoking, meat intake, pollution, calorie-dense diet), managing lifestyle, and increasing the consumption of antioxidants (vitamin C, vitamin E, alpha-lipoic acid, taurine, quercetin). Targeted therapies focusing on nitroso-redox imbalance can be critical for treatment of male reproductive dysfunction. This review outlines endogenous and exogenous sources of ROS/RNS, adverse effect on male reproduction, and strategies to control nitroso-redox imbalance.

Original languageEnglish (US)
Pages (from-to)968-977
Number of pages10
JournalTranslational Andrology and Urology
Issue number6
StatePublished - Dec 1 2018


  • Male reproduction
  • Nitric oxide synthase (NOS)
  • Nitroso-redox imbalance
  • Reactive nitrogen species (RNS)
  • Reactive oxygen species (ROS)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology


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