Effect of neuroprotective n-methyl-d-aspartate antagonists on increased intracranial pressure: Studies in the rat acute subdural hematoma model

Yasuhiro Kuroda, Hirosuke Fujisawa, Stephen Strebel, David I. Graham, Ross Bullock

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

GLUTAMATE ANTAGONISTS ARE the most powerful neuroprotective drugs in laboratory studies of focal cerebral ischemia. Because the majority of clinical conditions in which focal brain ischemia occurs are associated with high intracranial pressure (ICP), we have used the rat acute subdural hematoma model to evaluate the effects of three glutamate N-methyl-D- aspartate antagonists, MK-801, CGS 19755 (SELFOTEL), D-CPP-ene, and mannitol, upon ICP and also upon the volume of ischemic brain damage. Only mannitol produced a significant reduction in ICP and improved cerebral perfusion pressure. The three glutamate antagonists did not significantly affect ICP or cerebral perfusion pressure, but they were associated with a significantly smaller zone of focal brain damage, when compared to the mannitol and saline groups. N-methyl-D-aspartate antagonists do not increase ICP or jeopardize cerebral perfusion pressure when administered under anesthesia with a controlled PaCO2 level. Further studies in humans are indicated.

Original languageEnglish (US)
Pages (from-to)106-112
Number of pages7
JournalNeurosurgery
Volume35
Issue number1
DOIs
StatePublished - Jul 1994

Keywords

  • Acute subdural hematoma
  • Cerebral perfusion pressure
  • Focal brain ischemia
  • Glutamate
  • Increased intracranial pressure
  • N-methyl-D-aspartate antagonists

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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