Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets

Richard A. Burningham; Grace K. Arimura; Adel A. Yunis; W. J. Harrington

doi:10.3181/00379727-122-31233

Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets

Richard A. Burningham, Grace K. Arimura, Adel A. Yunis, W. J. Harrington

Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C¹⁴-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.

Original language	English (US)
Pages (from-to)	711-714
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	122
Issue number	3
DOIs	https://doi.org/10.3181/00379727-122-31233
State	Published - Jul 1966

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets",

abstract = "Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C14-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.",

author = "Burningham, {Richard A.} and Arimura, {Grace K.} and Yunis, {Adel A.} and Harrington, {W. J.}",

note = "Funding Information: This work was supported by USPHS grant AM 09001 from Nat. Inst. Health, grant P-391 from Am. Cancer Soc. and grant award from Upjohn Pharmaceutical Co., Kalamazoo, Mich. ",

year = "1966",

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doi = "10.3181/00379727-122-31233",

language = "English (US)",

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T1 - Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets

AU - Burningham, Richard A.

AU - Arimura, Grace K.

AU - Yunis, Adel A.

AU - Harrington, W. J.

N1 - Funding Information: This work was supported by USPHS grant AM 09001 from Nat. Inst. Health, grant P-391 from Am. Cancer Soc. and grant award from Upjohn Pharmaceutical Co., Kalamazoo, Mich.

PY - 1966/7

Y1 - 1966/7

N2 - Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C14-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.

AB - Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C14-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.

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Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets

Abstract

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