Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets

Richard A. Burningham, Grace K. Arimura, Adel A. Yunis, W. J. Harrington

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Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C14-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.

Original languageEnglish (US)
Pages (from-to)711-714
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Jul 1966


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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