Abstract
Monase indole-3(2-aminobu-tyl) acetate, a monoamine oxidase inhibitor, and 8 other structurally related compounds with different substitutions on the indole ring and amine side chain inhibited 5-HT uptake by platelets, degree of inhibition being directly related to concentration of inhibitor without particular relation to structure. C14-Mon-ase which differs from 5-HT by the absence of a hydroxyl group in position 5 of the indole ring and by the presence of a different side chain, was concentrated only slightly by platelets. It was concluded that the structural specificity for 5-HT uptake is largely determined by the hydroxyl group at position 5 of the indole ring.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 711-714 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 122 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 1966 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Burningham, R. A., Arimura, G. K., Yunis, A. A., & Harrington, W. J. (1966). Effect of Monase and Related Compounds on Uptake of 5-Hydroxytryptamine by Platelets. Proceedings of the Society for Experimental Biology and Medicine, 122(3), 711-714. https://doi.org/10.3181/00379727-122-31233