Mice bearing pulmonary metastases of the Lewis lung carcinoma were treated iv with a nonviable microbial vaccine following amputation of the primary inoculation site. The vaccine consisted of BCG cell wall skeleton, trehalose dimycolate, and endotoxin attached to mineral oil microdroplets. Single and repeated doses ranging from 15 to 675 μg were tested. Survival was modestly but consistently prolonged by vaccination. A portion of the activity appeared to be due to the Tween saline-oil vehicle. A single low dose (15 μg) was as efficacious as higher or repeated doses.
|Original language||English (US)|
|Number of pages||5|
|Journal||Cancer Treatment Reports|
|State||Published - Dec 1 1980|
ASJC Scopus subject areas
- Cancer Research