Effect of microbial fractions and vehicle on survival of mice bearing Lewis lung carcinoma

Stephen P Richman, V. T. Chism, S. G. Murphy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mice bearing pulmonary metastases of the Lewis lung carcinoma were treated iv with a nonviable microbial vaccine following amputation of the primary inoculation site. The vaccine consisted of BCG cell wall skeleton, trehalose dimycolate, and endotoxin attached to mineral oil microdroplets. Single and repeated doses ranging from 15 to 675 μg were tested. Survival was modestly but consistently prolonged by vaccination. A portion of the activity appeared to be due to the Tween saline-oil vehicle. A single low dose (15 μg) was as efficacious as higher or repeated doses.

Original languageEnglish
Pages (from-to)1329-1333
Number of pages5
JournalCancer Treatment Reports
Volume64
Issue number12
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Cell Wall Skeleton
Cord Factors
Lewis Lung Carcinoma
BCG Vaccine
Mineral Oil
Polysorbates
Amputation
Endotoxins
Oils
Vaccination
Vaccines
Neoplasm Metastasis
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effect of microbial fractions and vehicle on survival of mice bearing Lewis lung carcinoma. / Richman, Stephen P; Chism, V. T.; Murphy, S. G.

In: Cancer Treatment Reports, Vol. 64, No. 12, 01.12.1980, p. 1329-1333.

Research output: Contribution to journalArticle

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